MicroRNAs in the thyroid.

MicroRNAs in the thyroid.
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DOI:
10.1016/j.beem.2016.10.001
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发表时间:
2016-10
期刊:
Best practice & research. Clinical endocrinology & metabolism
影响因子:
--
通讯作者:
Kebebew E
Kebebew E
中科院分区:
其他
文献类型:
--
作者:
Boufraqech M;Klubo-Gwiezdzinska J;Kebebew E

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microRNA(miRNAs)是包含大约19-25个核苷酸的小的非编码RNA。miRNA可以作为肿瘤抑制因子或癌基因,并且已经在几种人类癌症中报道了miRNA的异常表达,并且已经与癌症的起始和进展相关。最近的证据表明,miRNAs在甲状腺癌的发生中起着重要作用。在这篇综述中,我们总结了甲状腺癌中的作用,并描述了致癌或肿瘤抑制功能的miRNA,以及其作为甲状腺癌的预后或诊断标志物的临床效用。
The microRNAs (miRNAs) are small non-coding RNA comprising approximately 19–25 nucleotides. miRNAs can act as tumour suppressors or oncogenes, and aberrant expression of miRNAs has been reported in several human cancers and has been associated with cancer initiation and progression. Recent evidence suggests that miRNAs play a major role in thyroid carcinogenesis. In this review, we summarize the role of miRNAs in thyroid cancer and describe the oncogenic or tumour suppressor function of miRNAs as well as their clinical utility as prognostic or diagnostic markers in thyroid cancer.
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