MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis.
MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis.
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DOI：
10.1093/nar/gky310
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发表时间：
2018-07-02
影响因子：
14.9
通讯作者：
Xia J
中科院分区：
文献类型：
--
作者：
Chong J;Soufan O;Li C;Caraus I;Li S;Bourque G;Wishart DS;Xia J
我们提出了一个新的更新的MetabAnalyst(版本4.0)，用于全面的代谢数据分析、解释和与其他组学数据的集成。自2015年最后一次重大更新以来，MetabAnalyst一直在根据用户反馈和该领域的技术进步而不断发展。对于今年的更新，MetbraAnalyst 4.0增加了四个新的关键功能，包括：(1)实时R命令跟踪和显示，以及配套的MetbraAnalystR软件包的发布；(2)MS Peaks to Path模块，用于使用Mummichog算法从非靶向质谱学数据预测途径活动；(3)Biomarker Meta-analysis模块，用于通过组合多个代谢组数据来稳健地识别生物标记物；(4)Network Explorer模块，用于代谢组学、元基因组学和/或转录组数据的综合分析。MetbraAnalyst 4.0的用户界面进行了重新设计，以提供更现代的外观，以及提供更多的空间和灵活性来引入新功能。基础知识库(化合物库、代谢物集合和代谢途径)也根据人类代谢组数据库(HMDB)的最新数据进行了更新。此外，还提供了Metover Analyst的Docker镜像，以方便下载和本地安装Metover Analyst。MetabAnalyst4.0可在http://metaboanalyst.ca.上免费获得
We present a new update to MetaboAnalyst (version 4.0) for comprehensive metabolomic data analysis, interpretation, and integration with other omics data. Since the last major update in 2015, MetaboAnalyst has continued to evolve based on user feedback and technological advancements in the field. For this year's update, four new key features have been added to MetaboAnalyst 4.0, including: (1) real-time R command tracking and display coupled with the release of a companion MetaboAnalystR package; (2) a MS Peaks to Pathways module for prediction of pathway activity from untargeted mass spectral data using the mummichog algorithm; (3) a Biomarker Meta-analysis module for robust biomarker identification through the combination of multiple metabolomic datasets and (4) a Network Explorer module for integrative analysis of metabolomics, metagenomics, and/or transcriptomics data. The user interface of MetaboAnalyst 4.0 has been reengineered to provide a more modern look and feel, as well as to give more space and flexibility to introduce new functions. The underlying knowledgebases (compound libraries, metabolite sets, and metabolic pathways) have also been updated based on the latest data from the Human Metabolome Database (HMDB). A Docker image of MetaboAnalyst is also available to facilitate download and local installation of MetaboAnalyst. MetaboAnalyst 4.0 is freely available at http://metaboanalyst.ca.
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影响因子：
48
作者：
Huan T;Forsberg EM;Rinehart D;Johnson CH;Ivanisevic J;Benton HP;Fang M;Aisporna A;Hilmers B;Poole FL;Thorgersen MP;Adams MWW;Krantz G;Fields MW;Robbins PD;Niedernhofer LJ;Ideker T;Majumder EL;Wall JD;Rattray NJW;Goodacre R;Lairson LL;Siuzdak G
通讯作者：
Siuzdak G
影响因子：
14.9
作者：
Hastings J;de Matos P;Dekker A;Ennis M;Harsha B;Kale N;Muthukrishnan V;Owen G;Turner S;Williams M;Steinbeck C
通讯作者：
Steinbeck C
影响因子：
21.3
作者：
Cox AG;Hwang KL;Brown KK;Evason K;Beltz S;Tsomides A;O'Connor K;Galli GG;Yimlamai D;Chhangawala S;Yuan M;Lien EC;Wucherpfennig J;Nissim S;Minami A;Cohen DE;Camargo FD;Asara JM;Houvras Y;Stainier DYR;Goessling W
通讯作者：
Goessling W
影响因子：
4.1
作者：
Chong J;Xia J
通讯作者：
Xia J
影响因子：
14.9
作者：
Kim S;Thiessen PA;Bolton EE;Chen J;Fu G;Gindulyte A;Han L;He J;He S;Shoemaker BA;Wang J;Yu B;Zhang J;Bryant SH
通讯作者：
Bryant SH