Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion.
Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion.
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DOI：
10.1016/j.brainres.2009.05.042
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发表时间：
2009-07-24
期刊：
影响因子：
2.9
通讯作者：
Huber JD
中科院分区：
文献类型：
--
作者：
Tan Z;Li X;Kelly KA;Rosen CL;Huber JD
年龄是中风的主要危险因素，在动物研究中经常被忽视。我们认为，使用老年动物可以深入了解中风损伤和恢复的各个方面，而这些方面在年轻动物中是被掩盖的，或者是没有引起的。在这项研究中，我们研究了共同管理的纤溶酶原激活物抑制剂1型衍生肽，EEIIMD，与组织纤溶酶原激活剂（tPA）对梗死体积和功能的结果在老年大鼠短暂的大脑中动脉闭塞。我们的研究结果显示，用EEIIMD沿着tPA治疗的老年（18-20个月）大鼠皮质梗死体积减少。然而，与仅给予tPA的老年大鼠相比，老年大鼠在总梗死体积、水肿形成或功能结局方面未显示出改善。用EEIIMD治疗的年轻成年大鼠（3-4个月）在皮质和总梗死体积、水肿形成和功能结局方面显示出显著改善。纹状体梗死体积不受EEIIMD治疗的年轻成年和老年大鼠。这些发现强调了年轻成年大鼠和老年大鼠之间存在的生理差异，并表明在评估中风时考虑衰老过程可能会提高我们辨别哪些治疗方法可以从实验室转移到床边的能力。
Age is a primary risk factor in stroke that is often overlooked in animal studies. We contend that using aged animals yields insight into aspects of stroke injury and recovery that are masked, or not elicited, in younger animals. In this study, we examined effects of co-administration of a plasminogen activator inhibitor type 1 derived peptide, EEIIMD, with tissue plasminogen activator (tPA) on infarct volume and functional outcome in aged rats following a transient middle cerebral artery occlusion. Results of our study showed aged (18–20 months) rats treated with EEIIMD along with tPA had reduced cortical infarction volume. However, aged rats showed no improvement in total infarction volume, edema formation, or functional outcome as compared to aged rats administered only tPA. Young adult rats (3–4 months) treated with EEIIMD showed significant improvement in cortical and total infarction volumes, edema formation, and functional outcome. Striatal infarction volume was unaffected by EEIIMD treatment in both young adult and aged rats. These findings emphasize that physiological differences exist between young adult and aged rats and suggest that taking aging processes into account when assessing stroke may improve our ability to discern which therapeutics can be translated from bench to bedside.
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