PLATELET ACTIVATION IN ACUTE CEREBRAL ISCHÆMIA Serial Measurements of Platelet Function in Cerebrovascular Disease
PLATELET ACTIVATION IN ACUTE CEREBRAL ISCHÆMIA Serial Measurements of Platelet Function in Cerebrovascular Disease
复制标题
急性脑缺血中的血小板活化 脑血管疾病中血小板功能的系列测量
DOI：
10.1016/s0140-6736(77)92774-x
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
B. Weksler
中科院分区：
文献类型：
--
作者：
J. Dougherty;D. Levy;B. Weksler
对82例急性脑缺血患者进行了体内循环血小板聚集体的连续测定和体外血小板聚集阈值的测定。53例完全性卒中患者（30.9%±2.0）和29例短暂性脑缺血发作患者（34.1%±2.3）的血小板聚集百分比增加，所有研究均在急性事件发生后10天内进行。这些值高于30例非血管性神经系统疾病患者的血小板聚集水平（16.8%±2.3）（p<0.001）。急性脑缺血后10天至6周，血小板聚集率恢复正常。阿司匹林和潘生丁并不影响这些患者循环血小板聚集水平的增加或随后的正常化。急性脑缺血患者的血小板聚集对二磷酸腺苷和肾上腺素的敏感性也增加，但这种异常在恢复期消失。血小板活化在急性脑缺血中是异常的，但通常在有或没有抗血小板治疗的情况下恢复正常。血小板的这种活化可能导致闭塞性血管疾病的临床表现。
Circulating platelet aggregates formed in vivo were serially measured, and platelet-aggregation thresholds were determined in vitro in 82 patients with acute cerebral ischæmia. The percentage of aggregated platelets was increased in 53 patients with completed stroke (30.9%±2.0) and in 29 patients with transient ischæmic attacks (34.1%±2.3), all studied within 10 days of the acute event. These values were higher (p<0.001) than levels of aggregated platelets in 30 patients with non-vascular neurological disease (16.8%±2.3). The percentage of aggregated platelets returned to normal 10 days to 6 wk after acute cerebral ischæmia. Aspirin and dipyridamole did not affect either the increase in or subsequent normalisation of circulating-platelet-aggregate levels in these patients. Platelet-aggregation sensitivity to adenosine diphosphate and adrenaline was also increased in patients with acute cerebral ischæmia, but this abnormality resolved during convalescence. Platelet activation is abnormal in acute cerebral ischæmia but usually returns to normal with or without anti-platelet therapy. This activation of platelets may contribute to the clinical manifestations of occlusive vascular disease.
使用脂质体封装的 ADP 激光诱导实验性血管闭塞。
影响因子：
2.4
作者：
Khoobehi,B;Peyman,GA;Bhatt,N;Moshfeghi,D
通讯作者：
Moshfeghi,D