Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
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DOI:
10.1016/j.cell.2009.01.042
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发表时间:
2009-02-20
期刊:
影响因子:
64.5
通讯作者:
Hinnebusch AG
中科院分区:
文献类型:
--
作者:
Sonenberg N;Hinnebusch AG
Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.
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