Ushering in the study and treatment of preclinical Alzheimer disease.
Ushering in the study and treatment of preclinical Alzheimer disease.
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DOI：
10.1038/nrneurol.2013.107
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Reiman EM
中科院分区：
文献类型：
--
作者：
Langbaum JB;Fleisher AS;Chen K;Ayutyanont N;Lopera F;Quiroz YT;Caselli RJ;Tariot PN;Reiman EM
研究人员已经开始描述阿尔茨海默病（AD）临床发作之前的微妙生物学和认知过程，并为加速评估实验性治疗以延迟发作，降低风险或完全防止临床衰退奠定基础。在这里，我们提供了一个概述的实验策略，脑成像和脑脊液生物标志物的措施，用于早期检测和跟踪的AD，突出的风险个人谁可能适合临床前监测。我们讨论了这些进展如何有助于AD作为一系列生物学变化的过程中发生的进展，从临床前AD，轻度认知障碍，最后痴呆症的重新概念化，我们审查最近提出的临床前AD的研究标准。临床前AD研究的进展促使人们认识到，至少一些AD疗法的疗效可能取决于在疾病临床表现之前开始治疗，从而开创了AD预防研究的新时代。
Researchers have begun to characterize the subtle biological and cognitive processes that precede the clinical onset of Alzheimer disease (AD), and to set the stage for accelerated evaluation of experimental treatments to delay the onset, reduce the risk of or completely prevent clinical decline. Here, we provide an overview of the experimental strategies, and brain imaging and cerebrospinal fluid biomarker measures that are used in early detection and tracking of AD, highlighting at-risk individuals who could be suitable for preclinical monitoring. We discuss how these advances have contributed to reconceptualization of AD as a sequence of biological changes that occur during progression from preclinical AD, to mild cognitive impairment and finally dementia, and we review recently proposed research criteria for preclinical AD. Advances in the study of preclinical AD have driven the recognition that efficacy of at least some AD therapies may depend on initiation of treatment before clinical manifestation of disease, leading to a new era of AD prevention research.
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影响因子：
12.7
作者：
Braak, Heiko;Del Tredici, Kelly
通讯作者：
Del Tredici, Kelly
影响因子：
3.7
作者：
Andrews KA;Modat M;Macdonald KE;Yeatman T;Cardoso MJ;Leung KK;Barnes J;Villemagne VL;Rowe CC;Fox NC;Ourselin S;Schott JM;Australian Imaging Biomarkers, Lifestyle Flagship Study of Ageing
通讯作者：
Australian Imaging Biomarkers, Lifestyle Flagship Study of Ageing
影响因子：
14
作者：
通讯作者：
--
DOI：
10.1080/13803390601174151
发表时间：
2007-11-01
影响因子：
2.2
作者：
Arango-Lasprilia, Juan Carlos;Cuetos, Fernando;Lopera, Francisco
通讯作者：
Lopera, Francisco
DOI：
10.1001/jama.2010.2008
发表时间：
2011-01-19
期刊：
JAMA
影响因子：
--
作者：
Clark CM;Schneider JA;Bedell BJ;Beach TG;Bilker WB;Mintun MA;Pontecorvo MJ;Hefti F;Carpenter AP;Flitter ML;Krautkramer MJ;Kung HF;Coleman RE;Doraiswamy PM;Fleisher AS;Sabbagh MN;Sadowsky CH;Reiman EP;Zehntner SP;Skovronsky DM;AV45-A07 Study Group
通讯作者：
AV45-A07 Study Group