Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
复制标题
DOI：
10.1038/s41588-018-0117-9
复制
发表时间：
2018-06
期刊：
影响因子：
30.8
通讯作者：
Dunstan SJ
中科院分区：
文献类型：
--
作者：
Holt KE;McAdam P;Thai PVK;Thuong NTT;Ha DTM;Lan NN;Lan NH;Nhu NTQ;Hai HT;Ha VTN;Thwaites G;Edwards DJ;Nath AP;Pham K;Ascher DB;Farrar J;Khor CC;Teo YY;Inouye M;Caws M;Dunstan SJ
为了研究从越南胡志明市结核病患者中分离出的结核分枝杆菌的传播动力学，我们对1,635个分离株的全基因组进行了测序，并将其与来自其他地方的3,144个分离株进行了比较。数据揭示了与长期潜伏感染的激活相关的地方性Mtb谱系1引起的潜在疾病负担，以及与最近引入的北京谱系和谱系4 Mtb菌株相关的三倍高负担。我们发现，北京谱系结核分枝杆菌在越南和其他国家之间频繁转移，并检测到北京谱系菌株在该宿主人群中的传播水平高于地方性谱系1结核分枝杆菌。在其他结核分枝杆菌谱系中筛选北京谱系相关SNP的平行进化作为阳性选择的信号，我们确定了ESX-5 VII型分泌蛋白EsxW中的突变，这可能有助于增强北京谱系结核分枝杆菌在越南和其他宿主人群中的传播。
To examine transmission dynamics of Mtb isolated from TB patients in Ho Chi Minh City, Vietnam we sequenced whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data reveal an underlying burden of disease caused by endemic Mtb Lineage 1 associated with activation of long-term latent infection, and a three-fold higher burden associated with more recently introduced Beijing lineage and Lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than endemic Lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify a mutation in the ESX-5 type VII secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations.
登录
查看更多内容
影响因子：
16.6
作者：
Bradley P;Gordon NC;Walker TM;Dunn L;Heys S;Huang B;Earle S;Pankhurst LJ;Anson L;de Cesare M;Piazza P;Votintseva AA;Golubchik T;Wilson DJ;Wyllie DH;Diel R;Niemann S;Feuerriegel S;Kohl TA;Ismail N;Omar SV;Smith EG;Buck D;McVean G;Walker AS;Peto TE;Crook DW;Iqbal Z
通讯作者：
Iqbal Z
影响因子：
4.6
作者：
Coppola M;van Meijgaarden KE;Franken KL;Commandeur S;Dolganov G;Kramnik I;Schoolnik GK;Comas I;Lund O;Prins C;van den Eeden SJ;Korsvold GE;Oftung F;Geluk A;Ottenhoff TH
通讯作者：
Ottenhoff TH
影响因子：
16.6
作者：
Eldholm, Vegard;Monteserin, Johana;Rieux, Adrien;Lopez, Beatriz;Sobkowiak, Benjamin;Ritacco, Viviana;Balloux, Francois
通讯作者：
Balloux, Francois
影响因子：
3
作者：
Bollback JP
通讯作者：
Bollback JP
影响因子：
9.5
作者：
Carver, Tim;Harris, Simon R.;McQuillan, Jacqueline A.
通讯作者：
McQuillan, Jacqueline A.