The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells.
The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells.
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DOI：
10.1016/j.semcancer.2012.04.006
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发表时间：
2012-10
影响因子：
14.5
通讯作者：
McAllister SS
中科院分区：
文献类型：
--
作者：
Castaño Z;Fillmore CM;Kim CF;McAllister SS
肿瘤越来越被认为是一种复杂性接近甚至可能超过健康组织的器官。从这个角度来看，只有通过研究肿瘤细胞的异质性和在肿瘤发生和恶性进展过程中构建的微环境，才能理解肿瘤的生物学。最近的研究揭示了癌症干细胞的存在，即具有自我更新和肿瘤繁殖能力的“虫子”。此外，现在认识到肿瘤微环境，即“床”，在支持癌症干细胞方面起着关键作用，并且还可能促进瘤形成和恶性进展。癌症的细胞内在特征的相互依赖性，包括癌症干细胞“虫子”和肿瘤微环境“床”，才刚刚开始被理解。在这篇综述中，我们强调了肿瘤干细胞及其微环境之间相互作用的快速发展的概念，从研究其正常组织对应物中获得的见解，以及围绕这一研究领域的问题和争议，重点是乳腺癌和肺癌。最后，我们讨论了支持以下观点的证据：消除床和虫子应该会带来更有效和个性化的癌症治疗，从而改善患者的预后。
Tumors have been increasingly recognized as organs with a complexity that approaches, and may even exceed, that of healthy tissues. When viewed from this perspective, the biology of a tumor can be understood only by studying tumor cell heterogeneity and the microenvironment that is constructed during the course of tumorigenesis and malignant progression. Recent work has revealed the existence of cancer stem cells, the “bugs”, with the capacity for self-renewal and tumor propagation. In addition, it is now recognized that the tumor microenvironment, the “bed”, plays a critical role in supporting cancer stem cells and also may promote neoplasia and malignant progression. The interdependence of the cell-intrinsic features of cancer, including the cancer stem cell “bugs” and the tumor microenvironment “bed”, is only beginning to be understood. In this review, we highlight the rapidly evolving concepts about the interactions between tumor stem cells and their microenvironment, the insights gained from studying their normal tissue counterparts, and the questions and controversies surrounding this area of research, with an emphasis on breast and lung cancer. Finally, we address evidence supporting the notion that eliminating the bed as well as the bugs should lead to more effective and personalized cancer treatments that improve patient outcome.
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影响因子：
10.5
作者：
Dontu, G;Abdallah, WM;Wicha, MS
通讯作者：
Wicha, MS
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
15.9
作者：
Chapman, Harold A.;Li, Xiaopeng;Vu, Thiennu H.
通讯作者：
Vu, Thiennu H.
DOI：
10.1073/pnas.1102454108
发表时间：
2011-05-10
影响因子：
11.1
作者：
Chaffer, Christine L.;Brueckmann, Ines;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
影响因子：
50.3
作者：
DeNardo DG;Barreto JB;Andreu P;Vasquez L;Tawfik D;Kolhatkar N;Coussens LM
通讯作者：
Coussens LM