CPPsite: a curated database of cell penetrating peptides.
CPPsite: a curated database of cell penetrating peptides.
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DOI：
10.1093/database/bas015
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Raghava GP
中科院分区：
文献类型：
--
作者：
Gautam A;Singh H;Tyagi A;Chaudhary K;Kumar R;Kapoor P;Raghava GP
将药物分子输送到细胞中是药物开发过程中的主要挑战之一。过去，细胞穿透肽已成功用于将多种治疗分子递送到各种类型的细胞中以治疗多种疾病。这些肽具有独特的能力，可以进入几乎任何类型的细胞内部。由于 CPP 的巨大治疗应用，我们建立了细胞穿透肽的综合数据库“CPPsite”，其中信息来自文献和专利。 CPPsite 是一个手动管理的数据库，包含经过实验验证的 843 个 CPP。每个条目提供了肽的信息，包括ID、PubMed ID、肽名称、肽序列、手性、来源、肽性质、亚细胞定位、摄取效率、摄取机制、疏水性、氨基酸频率和组成等。该数据库中纳入了各种用户友好的工具，如搜索、浏览、分析、绘图工具。此外，我们还从这些肽序列中获得了各种类型的信息，包括肽的二级/三级结构、氨基酸组成和理化性质。该数据库对于开发预测有效细胞穿透肽的模型非常有用。数据库网址：http://crdd.osdd.net/raghava/cppsite/。
Delivering drug molecules into the cell is one of the major challenges in the process of drug development. In past, cell penetrating peptides have been successfully used for delivering a wide variety of therapeutic molecules into various types of cells for the treatment of multiple diseases. These peptides have unique ability to gain access to the interior of almost any type of cell. Due to the huge therapeutic applications of CPPs, we have built a comprehensive database ‘CPPsite’, of cell penetrating peptides, where information is compiled from the literature and patents. CPPsite is a manually curated database of experimentally validated 843 CPPs. Each entry provides information of a peptide that includes ID, PubMed ID, peptide name, peptide sequence, chirality, origin, nature of peptide, sub-cellular localization, uptake efficiency, uptake mechanism, hydrophobicity, amino acid frequency and composition, etc. A wide range of user-friendly tools have been incorporated in this database like searching, browsing, analyzing, mapping tools. In addition, we have derived various types of information from these peptide sequences that include secondary/tertiary structure, amino acid composition and physicochemical properties of peptides. This database will be very useful for developing models for predicting effective cell penetrating peptides. Database URL: http://crdd.osdd.net/raghava/cppsite/.
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影响因子：
9.7
作者：
Aroui, Sonia;Brahim, Souhir;Kenani, Abderraouf
通讯作者：
Kenani, Abderraouf
DOI：
10.1073/pnas.78.6.3824
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HOPP, TP;WOODS, KR
通讯作者：
WOODS, KR
影响因子：
3.4
作者：
Eiriksdottir, Emelia;Konate, Karidia;Deshayes, Sebastien
通讯作者：
Deshayes, Sebastien
影响因子：
11.2
作者：
Batchu, RB;Moreno, AM;van Rhee, F
通讯作者：
van Rhee, F
影响因子：
4.5
作者：
Duchardt, Falk;Fotin-Mleczek, Mariola;Brock, Roland
通讯作者：
Brock, Roland