Refractive index measurement of the isolated crystalline lens using optical coherence tomography.
Refractive index measurement of the isolated crystalline lens using optical coherence tomography.
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DOI：
10.1016/j.visres.2008.09.010
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发表时间：
2008-12
期刊：
影响因子：
1.8
通讯作者：
Parel JM
中科院分区：
文献类型：
--
作者：
Uhlhorn SR;Borja D;Manns F;Parel JM
光学相干层析成像系统已被开发，是专门设计用于成像的孤立的晶体透镜。在来自32名年龄范围为6 - 82岁的人类供体的40枚晶状体上记录横截面OCT图像。提出了一种从一幅记录图像测量透镜轴向厚度和平均折射率的方法。使用来自文献的透镜色散数据，将在825 nm的测量波长下测量的平均群折射率转换为在589 nm下的平均相折射率。测量的所有晶状体的平均折射率为1.408 ± 0.005，与最近透镜折射率梯度的MRI测量结果一致。数据的线性回归导致平均折射率随年龄的统计学显著降低，但简单的线性模型不足以解释年龄依赖性。这里给出的结果表明，原子核中的峰值折射率更接近1.420，而不是先前接受的值1.406。
An optical coherence tomography system has been developed that was designed specifically for imaging the isolated crystalline lens. Cross-sectional OCT images were recorded on 40 lenses from 32 human donors with an age range of 6 – 82 years. A method has been developed to measure the axial thickness and average refractive index of the lens from a single recorded image. The measured average group refractive index at the measurement wavelength of 825 nm was converted to the average phase refractive index at 589 nm using lens dispersion data from the literature. The average refractive index for all lenses measured was 1.408 ± 0.005 which agrees well with recent MRI measurements of the lens index gradient. A linear regression of the data resulted in a statistically significant decrease in the average refractive index with age, but a simple linear model was insufficient to explain the age dependence. The results presented here suggest that the peak refractive index in the nucleus is closer to 1.420, rather than the previously accepted value of 1.406.
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影响因子：
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发表时间：
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