Altered neural networks and cognition in a hereditary colon cancer.
Altered neural networks and cognition in a hereditary colon cancer.
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DOI：
10.1016/j.ibneur.2021.09.007
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发表时间：
2021-12
影响因子：
1.5
通讯作者：
Cruz-Correa M
中科院分区：
文献类型：
--
作者：
Cali RJ;Nephew BC;Moore CM;Chumachenko S;Sala AC;Cintron B;Luciano C;King JA;Hooper SR;Giardiello FM;Cruz-Correa M
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disorder caused by mutation of the APC gene presenting with numerous colorectal adenomatous polyps and a near 100% risk of colon cancer. Preliminary research findings from our group indicate that FAP patients experience significant deficits across many cognitive domains. In the current study, fMRI brain metrics in a FAP population and matched controls were used to further the mechanistic understanding of reported cognitive deficits. This research identified and characterized any possible differences in resting brain networks and associations between neural network changes and cognition from 34 participants (18 FAP patients, 16 healthy controls). Functional connectivity analysis was performed using FSL with independent component analysis (ICA) to identify functional networks. Significant differences between cases and controls were observed in 8 well-established resting state networks. With the addition of an aggregate cognitive measure as a covariate, these differences were virtually non-existent, indicating a strong correlation between cognition and brain activity at the network level. The data indicate robust and pervasive effects on functional neural network activity among FAP patients and these effects are likely involved in cognitive deficits associated with this disease.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
1.7
作者：
Azofra AS;Kidambi TD;Jeremy RJ;Conrad P;Blanco A;Myers M;Barkovich J;Terdiman JP
通讯作者：
Terdiman JP
影响因子：
5.3
作者：
Hickman, Tyler T.;Liberman, M. Charles;Jacob, Michele H.
通讯作者：
Jacob, Michele H.
影响因子：
3.2
作者：
Corbetta, M;Kincade, JM;Shulman, GL
通讯作者：
Shulman, GL
影响因子：
3.5
作者：
Gjone, H.;Diseth, T. H.;Heiberg, A.
通讯作者：
Heiberg, A.