"CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.
"CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.
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DOI：
10.1016/j.jconrel.2021.08.059
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发表时间：
2021-10-10
期刊：
影响因子：
--
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Yang X;Lu W;Wang M;Tan C;Wang B
沿着在理解一氧化碳（CO）的内源性信号作用和作用机制方面的令人印象深刻的成就，许多研究已经证明了使用CO作为治疗剂用于治疗各种疾病的潜力。由于CO的毒性在高浓度和所观察到的差异的毒性档案的CO取决于给药途径，本综述分析和提出的好处，开发口服活性CO捐助者。这些化合物具有改善安全性的潜力，增加了开发基于CO的治疗剂的机会。在这篇综述中，吸入和口服给药的毒性，CO输送效率和潜在的作用机制（S）的差异进行了分析。通过总结迄今为止发表的研究，也广泛分析了从CO气体吸入到口服给药的演变。“药丸中的CO”的概念可以通过口服施用CO气体或适当的CO供体的新制剂来实现。
Along with the impressive achievements in understanding the endogenous signaling roles and mechanism(s) of action of carbon monoxide (CO), much research has demonstrated the potential of using CO as a therapeutic agent for treating various diseases. Because of CO’s toxicity at high concentrations and the observed difference in toxicity profiles of CO depending on the route of administration, this review analyzes and presents the benefits of developing orally active CO donors. Such compounds have the potential for improved safety profiles, enhancing the chance for developing CO-based therapeutics. In this review, the difference between inhalation and oral administration in terms of toxicity, CO delivery efficiency, and the potential mechanism(s) of action is analyzed. The evolution from CO gas inhalation to oral administration is also extensively analyzed by summarizing published studies up to date. The concept of “CO in a pill” can be achieved by oral administration of novel formulations of CO gas or appropriate CO donors.
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