Integral membrane proteins and bilayer proteomics.
Integral membrane proteins and bilayer proteomics.
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DOI:
10.1021/ac303064a
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发表时间:
2013-03-05
影响因子:
7.4
通讯作者:
Whitelegge JP
中科院分区:
文献类型:
--
作者:
Whitelegge JP
Integral membrane proteins reside within the bilayer membranes that surround cells and organelles, playing critical roles in movement of molecules across them and the transduction of energy and signals. While their extreme amphipathicity presents technical challenges, biological mass spectrometry has been applied to all aspects of membrane protein chemistry and biology, including analysis of primary, secondary, tertiary and quaternary structure, as well as the dynamics that accompany functional cycles and catalysis.
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