The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.
复制标题
DOI：
10.1016/j.dnarep.2014.03.023
复制
发表时间：
2014-07
期刊：
影响因子：
3.8
通讯作者：
Cimprich, Karlene A.
中科院分区：
文献类型：
--
作者：
Hamperl, Stephan;Cimprich, Karlene A.
关键词：
准确的DNA复制和DNA修复对于维持基因组稳定性至关重要，并且通常认为这些过程的失败是细胞中DNA损伤的主要来源。有趣的是，最近的证据表明，DNA损伤更可能发生在具有高转录活性的基因组位点。此外，真核细胞中某些RNA加工因子的丢失与称为R环的共转录RNA：DNA杂合结构的形成增加有关，导致双链断裂（DSB）和DNA损伤。然而，R-环结构最终导致DNA断裂和基因组不稳定的分子机制还不清楚。在这篇综述中，我们总结了目前的知识的形成，识别和加工的RNA：DNA杂交体，并讨论了可能的机制，这些结构有助于DNA损伤和基因组不稳定的细胞。
Accurate DNA replication and DNA repair are crucial for the maintenance of genome stability, and it is generally accepted that failure of these processes is a major source of DNA damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to occur at genomic loci with high transcriptional activity. Furthermore, loss of certain RNA processing factors in eukaryotic cells is associated with increased formation of co-transcriptional RNA:DNA hybrid structures known as R-loops, resulting in double-strand breaks (DSBs) and DNA damage. However, the molecular mechanisms by which R-loop structures ultimately lead to DNA breaks and genome instability is not well understood. In this review, we summarize the current knowledge about the formation, recognition and processing of RNA:DNA hybrids, and discuss possible mechanisms by which these structures contribute to DNA damage and genome instability in the cell.
登录
查看更多内容
影响因子：
3.2
作者：
Baaklini, Imad;Usongo, Valentine;Drolet, Marc
通讯作者：
Drolet, Marc
酿酒酵母中RNase H2损失的转录反应。
影响因子：
3.8
作者：
Arana, Mercedes E.;Kerns, Robnet T.;Wharey, Laura;Gerrish, Kevin E.;Bushel, Pierre R.;Kunkel, Thomas A.
通讯作者：
Kunkel, Thomas A.
DOI：
10.1038/nrg3296
发表时间：
2012-11
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
14.9
作者：
Chon H;Sparks JL;Rychlik M;Nowotny M;Burgers PM;Crouch RJ;Cerritelli SM
通讯作者：
Cerritelli SM
影响因子：
3.6
作者：
Baaklini, I;Hraiky, C;Drolet, M
通讯作者：
Drolet, M