The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine.
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine.
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DOI：
10.1016/j.bbagen.2009.07.017
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发表时间：
2010-02
影响因子：
3
通讯作者：
Love, Dona C.
中科院分区：
文献类型：
--
作者：
Hanover, John A.;Krause, Michael W.;Love, Dona C.
关键词：
O-GlcNAc循环的酶将UDP-GlcNAc的营养依赖性合成偶联至关键核和细胞质靶的Ser/Thr残基的O-GlcNAc修饰。这一系列反应最终导致目标的O-GlcNAc酰化，被称为己糖胺信号通路（HSP）。进化上古老的O-GlcNAc循环酶与其他信号效应分子共同进化;它们通过许多用于组织经典激酶依赖性信号通路的相同机制被招募到其靶标。O-GlcNAc循环酶的这种共募集驱动影响生长和生长途径（营养吸收）和分解代谢途径（营养节约和补救）的二元开关。因此，己糖胺信号通路（HSP）已成为调节影响生长、代谢、细胞应激、昼夜节律和宿主-病原体相互作用的众多细胞信号级联的多功能细胞调节剂。在哺乳动物中，营养感应HSP已被利用来调节诸如中性粒细胞迁移以及B细胞和T细胞的活化等细胞特异性功能。这篇综述总结了不同的方法被用来检查O-GlcNAc循环。它将强调O-GlcNAcylation对信号通路的影响，这些信号通路可能在免疫系统疾病、糖尿病、癌症、心血管疾病和神经退行性疾病中被解除管制。
The enzymes of O-GlcNAc cycling couple the nutrient-dependent synthesis of UDP-GlcNAc to O-GlcNAc modification of Ser/Thr residues of key nuclear and cytoplasmic targets. This series of reactions culminating in O-GlcNAcylation of targets has been termed the Hexosamine Signaling Pathway (HSP). The evolutionarily ancient enzymes of O-GlcNAc cycling have co-evolved with other signaling effecter molecules; they are recruited to their targets by many of the same mechanisms used to organize canonic kinase-dependent signaling pathways. This co-recruitment of the enzymes of O-GlcNAc cycling drives a binary switch impacting pathways of anabolism and growth (nutrient uptake) and catabolic pathways (nutrient sparing and salvage). The Hexosamine Signaling Pathway (HSP) has thus emerged as a versatile cellular regulator modulating numerous cellular signaling cascades influencing growth, metabolism, cellular stress, circadian rhythm, and host-pathogen interactions. In mammals, the nutrient-sensing HSP has been harnessed to regulate such cell-specific functions as neutrophil migration, and activation of B-cells and T-cells. This review summarizes the diverse approaches being used to examine O-GlcNAc cycling. It will emphasize the impact O-GlcNAcylation has upon signaling pathways that may be become deregulated in diseases of the immune system, diabetes mellitus, cancer, cardiovascular disease, and neurodegenerative diseases.
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DOI：
10.1006/mcbr.2001.0300
发表时间：
2001-11-01
期刊：
Molecular Cell Biology Research Communications
影响因子：
--
作者：
Berman, Kevin;McKay, Jim;Cobb, Melanie
通讯作者：
Cobb, Melanie
影响因子：
5.5
作者：
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通讯作者：
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影响因子：
1.8
作者：
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通讯作者：
Kawakami, Hayato
影响因子：
4.3
作者：
Banerjee, Sulagna;Robbins, Phillips W.;Samuelson, John
通讯作者：
Samuelson, John
影响因子：
4.7
作者：
Cole, RN;Hart, GW
通讯作者：
Hart, GW