Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients.
Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients.
复制标题
DOI：
10.1186/1756-9966-29-85
复制
发表时间：
2010-06-30
期刊：
影响因子：
--
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Ma Y;Ma L;Guo Q;Zhang S
检测骨形态发生蛋白2（BMP-2）及其受体BMPRIA、BMPRIB、BMPRII在上皮性卵巢癌（EOC）中的表达情况，分析其对卵巢癌患者预后的影响。采用半定量RT-PCR和Western blot方法检测EOC、良性卵巢肿瘤和正常卵巢组织中BMP-2及其受体BMPRIA、BMPRIB和BMPRII mRNA和蛋白水平的表达情况。采用免疫组化法检测100例EOC患者中BMP-2及其受体的表达情况，分析其对卵巢癌患者五年生存率和生存时间的影响。 (1)卵巢癌组织中BMP-2、BMPRIB、BMPRII mRNA和蛋白表达量显着低于卵巢良性肿瘤和正常卵巢组织,而BMPRIA表达量在3种组织中无显着差异。 (2)BMP-2、BMPRIB、BMPRII阳性表达的EOC患者的五年生存率及术后平均生存时间显着高于BMP-2、BMPRIB、BMPRII阴性表达的患者。 BMPRIA 表达与卵巢癌患者的五年生存率或平均生存时间无关。 BMP-2、BMPRIB和BMPRII在EOC组织中表现出低表达，表达的变化或缺失可能表明卵巢癌患者预后不良。
To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian cancer patients. Semi-quantitative RT-PCR and western blot were applied to detect the expression of BMP-2 and its receptors BMPRIA, BMPRIB, and BMPRII in EOC, benign ovarian tumors, and normal ovarian tissue at the mRNA and protein levels. Immunohistochemistry was used to determine the expression of BMP-2 and its receptors in 100 patients with EOC to analyze their influence on the five-year survival rate and survival time of ovarian cancer patients. (1) The mRNA and protein expression levels of BMP-2, BMPRIB, and BMPRII in ovarian cancer tissue were remarkably lower than those in benign ovarian tumors and normal ovarian tissue, while no significant differences in BMPRIA expression level was found among the three kinds of tissues. (2) The five-year survival rate and the average survival time after surgery of EOC patients with positive expression of BMP-2, BMPRIB, and BMPRII were remarkably higher than those of patients with negative expression of BMP-2, BMPRIB, and BMPRII. BMPRIA expression was not associated with the five-year survival rate or with the average survival time of ovarian cancer patients. BMP-2, BMPRIB, and BMPRII exhibited low expression in EOC tissue, and variation or loss of expression may indicate poor prognosis for ovarian cancer patients.
登录
查看更多内容
影响因子：
4.7
作者：
Langenfeld, EM;Calvano, SE;Langenfeld, J
通讯作者：
Langenfeld, J
影响因子：
3.5
作者：
Waite, KA;Eng, C
通讯作者：
Eng, C
影响因子：
3.5
作者：
Ni, XH;Gu, SH;Mao, YM
通讯作者：
Mao, YM
影响因子：
29.4
作者：
Hardwick, JCH;Van den Brink, GR;Peppelenbosch, MP
通讯作者：
Peppelenbosch, MP
DOI：
10.1016/s0006-291x(02)02977-7
发表时间：
2003-01-31
影响因子：
3.1
作者：
Dumont, N;Arteaga, CL
通讯作者：
Arteaga, CL