Metal deposition in calcific uremic arteriolopathy.
Metal deposition in calcific uremic arteriolopathy.
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DOI：
10.1016/j.jaad.2009.01.042
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发表时间：
2009-07
影响因子：
13.8
通讯作者：
Swaminathan, Sundararaman
中科院分区：
文献类型：
--
作者：
Amuluru, Lavanya;High, Whitney;Hiatt, Kim M.;Ranville, James;Shah, Sudhir V.;Malik, Bilal;Swaminathan, Sundararaman
钙化性尿毒症动脉病(CUA)是一种通常致命的疾病，影响终末期肾病患者。尽管动物研究支持金属在慢性萎缩性胃炎发病机制中的作用，但金属在人体组织中的积聚以前没有被评估过。目的：评价CUA内金属沉积情况。从UAMS皮肤病理学数据库中鉴定出12例经组织学证实的CUA病例。5例慢性肾脏疾病患者的皮肤活检作为对照，这些患者暴露于Gd造影剂，但没有CUA。使用电感耦合质谱仪对皮损皮肤中的铁、铝和Gd等金属进行定量。有7名患者在CUA前2年内有暴露于基于Gd的造影剂的记录。其中3例并发肾源性全身性纤维化。与对照组相比，在CUA样本中检测到了非常显著的铁(p=0.03)和铝(p=0.0002)。在几个CUA活组织检查中发现了大量的Gd。观察性、回溯性研究设计，样本量小。CUA中组织铁、铝含量增加。在一些CUA标本中也存在大量的Gd。基于金属与CUA发病机制密切相关的动物研究，我们的数据提示金属沉积在人类CUA的发病机制中应被考虑。
Calcific uremic arteriolopathy (CUA) is an often fatal disease that affects patients with end stage renal disease. Although animal studies support a role for metals in the pathogenesis of CUA, metal accumulation in human tissue has not been previously evaluated. To evaluate metal deposition in CUA. Twelve histologically proven cases of CUA were identified from the UAMS dermatopathology database. Five skin biopsies from chronic kidney disease patients exposed to gadolinium contrast but without CUA were used as controls. Quantification of metals including iron, aluminum and gadolinium in the lesional skin was performed using inductively coupled mass spectrometry. Seven patients had documented exposure to gadolinium-based contrast in the preceding 2 years before CUA. Three of them had concurrent nephrogenic systemic fibrosis. Highly significant quantities of iron (p=0.03), and aluminum (p=0.0002) were detected in CUA specimens compared to controls. Significant amounts of gadolinium were present in several CUA biopsies. Observational, retrospective study design and small sample size. Tissue iron and aluminum content is increased in CUA. A significant amount of gadolinium is also present in some CUA specimens. Based on animal studies which strongly implicate metals in the pathogenesis of CUA, our data suggest that metal deposition should be considered in the pathogenesis of human CUA.
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影响因子：
4.8
作者：
Byon, Chang Hyun;Javed, Amjad;Chen, Yabing
通讯作者：
Chen, Yabing
影响因子：
13.2
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Ahmed, S;O'Neill, KD;Moe, SM
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Moe, SM
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