Golgi compartmentation and identity.

Golgi compartmentation and identity.
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DOI:
10.1016/j.ceb.2014.04.010
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发表时间:
2014-08
影响因子:
7.5
通讯作者:
Glick, Benjamin S.
Glick, Benjamin S.
中科院分区:
生物学2区
文献类型:
--
作者:
Papanikou, Effrosyni;Glick, Benjamin S.

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最近的工作支持的想法,池的高尔基体可以被分配到三类,这对应于离散阶段的池成熟。每个阶段都有一个独特的膜交通模式。在第一阶段,在多功能膜组装站与ER一起形成池。在第二阶段,囊泡合成碳水化合物,同时通过COPI囊泡交换物质。在第三阶段,跨高尔基体网络的池分离成域,并在特定脂质和肌动蛋白细胞骨架的帮助下产生运输载体。这些过程由Rab和Arf/Arl GTP酶级联协调。
Recent work supports the idea that cisternae of the Golgi apparatus can be assigned to three classes, which correspond to discrete stages of cisternal maturation. Each stage has a unique pattern of membrane traffic. At the first stage, cisternae form in association with the ER at multifunctional membrane assembly stations. At the second stage, cisternae synthesize carbohydrates while exchanging material via COPI vesicles. At the third stage, cisternae of the trans-Golgi network segregate into domains and produce transport carriers with the aid of specific lipids and the actin cytoskeleton. These processes are coordinated by cascades of Rab and Arf/Arl GTPases.
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