Osteoarthritis year in review 2013: biology.

Osteoarthritis year in review 2013: biology.
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DOI:
10.1016/j.joca.2013.05.020
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发表时间:
2013-10
影响因子:
7
通讯作者:
Loeser, R. F.
Loeser, R. F.
中科院分区:
医学2区
文献类型:
--
作者:
Loeser, R. F.

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本综述的目的是介绍骨关节炎(OA)生物学主题的已发表文献的亮点。进行了PubMed检索,以查找自2012年OARSI上次会议以来发表的原始研究手稿。通过对已发表文献的回顾,共同的主题成为过去一年研究的活跃领域,包括表观遗传学、Wnt信号传导、炎症通路在OA中的作用、润滑素、成纤维细胞生长因子信号传导以及骨中OA生物学研究。在这些领域的主要研究结果进行了总结和未来的治疗进行了讨论。
The purpose of this review was to present highlights from the published literature on the topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate original research manuscripts published since the last OARSI meeting in 2012. From review of the published literature, common themes emerged as active areas of research over the past year including studies in the areas of epigenetics, Wnt signaling, the role of inflammatory pathways in OA, lubricin, fibroblast growth factor signaling, and studies on OA biology in bone. Key findings in these areas were summarized and implications for future therapies were discussed.
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