Defence against antimicrobial peptides: different strategies in Firmicutes.

Defence against antimicrobial peptides: different strategies in Firmicutes.
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防御抗菌肽:厚壁菌门的不同策略

DOI:
10.1111/1462-2920.12400
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发表时间:
2014
影响因子:
5.1
通讯作者:
Zúñiga
Zúñiga
中科院分区:
生物学2区
文献类型:
--
作者:
Revilla-Guarinos;Gebhard;Mascher;Zúñiga

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Firmicutes构成了一门细菌,可以在各种各样的栖息地中找到,从土壤到动物的胃肠道,它们必须在复杂的社区中茁壮成长。这些群落中的竞争通常涉及生产化合物,如抗菌肽(AMP),以消除竞争对手的生物体。动物和植物也产生AMP来控制它们相关的微生物群。反过来,防御机制已经发展到阻止这些化合物的作用。一些Firmicutes与人类作为主要病原体或寄生生物的密切联系,推动了对这些细菌对抗抗菌化合物的防御机制的大量研究。本文综述了两种针对AMP的防御机制的最新进展:D-丙氨酰化修饰细胞壁和肽抗生素特异性三磷酸腺苷结合盒转运蛋白的作用。
TheFirmicutesconstitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these communities usually involves the production of compounds such as antimicrobial peptides (AMPs) to eliminate competitor organisms. Animals and plants also produce AMPs to control their associated microbiota. In turn, defence mechanisms have evolved to prevent the action of these compounds. The close association of someFirmicuteswith humans as prominent pathogens or commensal organisms has driven a considerable research effort on defence mechanisms used by these bacteria against antimicrobial compounds. This review focuses on the most recent advances on two well‐characterized defence mechanisms against AMPs: the modification of the cell wall by D‐alanylation and the role of peptide antibiotic‐specific adenosine triphosphate‐binding cassette transporters.
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