Factors controlling nutrient availability to the developing fetus in ruminants.
Factors controlling nutrient availability to the developing fetus in ruminants.
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DOI：
10.1186/s40104-015-0012-5
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发表时间：
2015
影响因子：
7
通讯作者：
Satterfield MC
中科院分区：
文献类型：
--
作者：
Dunlap KA;Brown JD;Keith AB;Satterfield MC
营养物质输送不足会导致宫内生长受限（IUGR），这是牲畜新生儿发病和死亡的主要原因。在反刍动物中，由于频繁使用以粗饲料为基础的放牧系统，怀孕期间营养不足的情况常常普遍存在，使它们极易受到营养质量和可用性变化的影响。向胎儿输送营养物质取决于许多关键因素，包括胎盘生长和发育、子宫胎盘血流量、营养物质可用性以及胎盘代谢和运输能力。我们实验室和其他实验室之前的研究结果强调了氨基酸及其代谢物在支持正常胎儿生长和发育中的重要作用，以及氨基酸转运蛋白在向胎儿输送营养物质中的关键作用。本综述的重点是母体营养对胎盘形态和功能的作用，作为反刍动物胎儿发育的调节剂。
Inadequate delivery of nutrients results in intrauterine growth restriction (IUGR), which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placental metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of maternal nutrition on placental form and function as a regulator of fetal development in ruminants.
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