Conjugate ofβ-Lactoglobulin with Carboxymethyl Dextran Increased the Antigen-Specific IgG1 Production, While It Decreased IgE Production Compared with Native β-Lactoglobulin

Conjugate ofβ-Lactoglobulin with Carboxymethyl Dextran Increased the Antigen-Specific IgG1 Production, While It Decreased IgE Production Compared with Native β-Lactoglobulin
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与天然 β-乳球蛋白相比,β-乳球蛋白与羧甲基葡聚糖的缀合物增加了抗原特异性 IgG1 的产生,同时减少了 IgE 的产生

DOI:
10.1007/978-90-481-3892-0_22
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发表时间:
2010
期刊:
影响因子:
--
通讯作者:
M. Hattori
M. Hattori
中科院分区:
--
文献类型:
--
作者:
Tadashi Yoshida;Yuko Shigihara;Manami Nakamura;M. Hattori

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IgE是I型变态反应性疾病的关键因子。在这项研究中,我们研究了B细胞受体(BCR)信号在IgG 1和IgE类转换中的作用。具有修饰的表面结构的抗原从天然抗原诱导不同的IgE和IgG1产生。提示抗原与BCR之间的亲和力可能是决定IG类别转换的重要因素。
IgE is a critical factor of type I allergic diseases. We examined in this study the role of B cell receptor (BCR) signal in the class switching to IgG1 and IgE. An antigen with modified-surface structure induced distinct IgE and IgG1 production from native antigen. Our results suggest that the affinity between antigen and BCR might be involved in the determination of Ig class to switch.
DOI: 10.1046/j.0954-7894.2002.01354.x
发表时间: 2002-04-01
影响因子: 6.1
作者:
Shida, K;Takahashi, R;Kaminogawa, S
通讯作者: Kaminogawa, S