MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.

MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.
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DOI:
10.1093/bib/bbx108
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发表时间:
2019-07-19
影响因子:
9.5
通讯作者:
Yamada KD
Yamada KD
中科院分区:
生物学2区
文献类型:
--
作者:
Katoh K;Rozewicki J;Yamada KD

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本文介绍了多序列比对(MSA)的MAFFT在线服务中的几个功能。由于测序技术的最新进展,大量的生物序列是可用的,并且对具有大量序列的MSA的需求正在增加。为了从这些数据中提取生物相关信息,复杂的算法是必要的,但还不够。实验生物学家半自动处理大数据的直观和交互式工具变得越来越重要。我们正在朝着这两个方向开发MAFFT。在这里,我们解释(i)最近开发的大数据选项的Web界面和(ii)交互式使用,以完善序列数据集和MSA。
This article describes several features in the MAFFT online service for multiple sequence alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers of biological sequences are available and the need for MSAs with large numbers of sequences is increasing. To extract biologically relevant information from such data, sophistication of algorithms is necessary but not sufficient. Intuitive and interactive tools for experimental biologists to semiautomatically handle large data are becoming important. We are working on development of MAFFT toward these two directions. Here, we explain (i) the Web interface for recently developed options for large data and (ii) interactive usage to refine sequence data sets and MSAs.
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