Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants.
Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants.
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148,321名英国生物库参与者的白细胞端粒长度较短和高水平的维生素D与较短的白细胞端粒长度有关。
DOI：
10.3390/nu15061474
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发表时间：
2023-03-19
期刊：
影响因子：
5.9
通讯作者：
Duque G
中科院分区：
文献类型：
--
作者：
Kuo CL;Kirk B;Xiang M;Pilling LC;Kuchel GA;Kremer R;Duque G
背景资料：在多种与年龄相关的疾病中观察到较短的白细胞端粒长度（LTL），这些疾病也与维生素D缺乏有关（即，骨质疏松症、神经认知障碍、癌症、骨关节炎等），这表明维生素D和LTL之间存在密切联系。在这项研究中，我们研究了英国生物银行老年参与者中维生素D水平和LTL之间的关系。方法：数据来自英国生物银行。纳入了60岁及以上的参与者（n = 148，321）。使用多重qPCR技术测量基线LTL，并表示为端粒扩增产物（T）与单拷贝基因（S）的比率（T/S比率）。血清25-羟基维生素D（25 OHD）通过z评分分层，并在校正协变量的线性回归模型中与LTL相关。结果如下：与中等水平相比，（在16.6 nmol/L，29.7 nmol/L范围内）或极低血清25 OHD水平（≤16.6 nmol/L）与LTL较短相关：分别为0.018 SD（标准化β = −0.018，95% CI −0.033至−0.003，p = 0.022）和0.048 SD（标准化β = −0.048，95% CI −0.083至−0.014，p = 0.006）。此外，高血清25 OHD组（>95.9 nmol/L）的平均LTL比中等25 OHD水平组短0.038 SD（标准化β = −0.038，95% CI −0.072至−0.004，p = 0.030）。上述关联针对多个变量进行了调整。结论：在这项基于人群的研究中，我们发现LTL和维生素D状态之间存在倒U形关系。我们的发现可能会受到无法测量的混杂因素的影响。高或低维生素D相关的较短的LTL是否与年龄相关的疾病有关，仍有待阐明。
Background: Shorter leukocyte telomere length (LTL) is observed in multiple age-related diseases, which are also associated with vitamin D deficiency (i.e., osteosarcopenia, neurocognitive disorders, cancer, osteoarthritis, etc.), suggesting a close association between vitamin D and LTL. In this study, we examined the relationship between vitamin D levels and LTL in older participants of the UK Biobank. Methods: Data were collected from the UK Biobank. Participants aged 60 and older (n = 148,321) were included. Baseline LTL was measured using a multiplex qPCR technique and expressed as the ratio of the telomere amplification product (T) to that of a single-copy gene (S) (T/S ratio). Serum 25-hydroxyvitamin D (25OHD) was stratified by z score and linked to LTL in a linear regression model adjusting for covariates. Results: Compared to the medium level, a low (in the range of 16.6 nmol/L, 29.7 nmol/L) or extremely low (≤16.6 nmol/L) level of serum 25OHD was associated with shorter LTL: 0.018 SD (standardized β = −0.018, 95% CI −0.033 to −0.003, p = 0.022) and 0.048 SD (standardized β = −0.048, 95% CI −0.083 to −0.014, p = 0.006), respectively. Additionally, the high serum 25OHD groups (>95.9 nmol/L) had 0.038 SD (standardized β = −0.038, 95% CI −0.072 to −0.004, p = 0.030) shorter mean LTL than the group with medium 25OHD levels. The associations above were adjusted for multiple variables. Conclusions: In this population-based study, we identified an inverted U-shape relationship between LTL and vitamin D status. Our findings could be affected by unmeasured confounders. Whether high or low vitamin D-associated shorter LTL is mechanistically related to age-related conditions remains to be elucidated.
影响因子：
3.7
作者：
Agirbasli D;Kalyoncu M;Muftuoglu M;Aksungar FB;Agirbasli M
通讯作者：
Agirbasli M