An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke.
An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke.
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急性缺血性中风血管内桥接治疗的荟萃分析概述
DOI：
10.1155/2018/9831210
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发表时间：
2018
影响因子：
--
通讯作者：
Xie CL
中科院分区：
文献类型：
--
作者：
Chen SY;Zhang XR;Chen J;Ge WQ;Wang WW;Wang XS;Xie CL
Background Acute Ischemic Stroke (AIS) is a common cause of death worldwide and the leading cause of long-term severe disability. Endovascular bridging therapies (EBT), including endovascular thrombectomy (ET) and intra-arterial thrombolytic (IAT), have been recommended to realize a favorable functional outcome for AIS patients. Methods An overview of meta-analyses of primary randomized controlled trial (RCT) studies was performed evaluating EBT for AIS patients compared with usual care. Results Ten meta-analyses were included in this overview. ET was associated with a higher incidence of achieving functional outcome improvement, defined as a modified Rankin scale of 0 to 1 (mRS, p = 0.003), 0 to 2 (p < 0.00001), and 0 to 3 (p = 0.005). The risk of symptomatic intracranial hemorrhage (sICH) rate and all-cause mortality were similar between the two groups. Moreover, IAT treatment was also related to significantly improved outcomes in terms of the mRS score (p < 0.05), but no significant difference in rates of sICH and mortality within 90 days. Conclusions In conclusion, our analysis supports that EBT, regardless of format (e.g., ET or IAT), is superior to the best medical therapy alone (e.g., IVT) in terms of mRS score in patients with AIS. In addition, the safety of EBT is similar to IVT.
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影响因子：
37.8
作者：
Meyers PM;Schumacher HC;Connolly ES Jr;Heyer EJ;Gray WA;Higashida RT
通讯作者：
Higashida RT
影响因子：
3.7
作者：
Ma QF;Chu CB;Song HQ
通讯作者：
Song HQ
影响因子：
8.3
作者：
Jauch, Edward C.;Saver, Jeffrey L.;Yonas, Howard
通讯作者：
Yonas, Howard
影响因子：
24
作者：
Elgendy, Islam Y.;Kumbhani, Dharam J.;Bavry, Anthony A.
通讯作者：
Bavry, Anthony A.
影响因子：
8.3
作者：
Saqqur, Maher;Uchino, Ken;Alexandrov, Andrei V.
通讯作者：
Alexandrov, Andrei V.