Cell signaling during development of Dictyostelium.
Cell signaling during development of Dictyostelium.
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DOI：
10.1016/j.ydbio.2014.04.001
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Loomis, William F.
中科院分区：
文献类型：
--
作者：
Loomis, William F.
细胞间的持续交流对于任何多细胞生物体的发育都是必要的，并依赖于对分泌信号的识别。广泛的分子包括蛋白质、多肽、氨基酸、核酸、类固醇和多酮类化合物，在动植物中被用作细胞间信号。当单细胞聚集形成多细胞结构时，它们也用于在社会变形虫Dictyostelialdiscoideum中进行交流。许多信号是由表面受体识别的，表面受体是连接到三聚体G蛋白的七个跨膜蛋白，将信号传递到细胞质中的成分。网柄苔藓细胞必须判断何时达到足够的细胞密度，以保证从生长到分化的转变。他们必须意识到外源营养何时变得有限，然后同步启动发育。几个小时后，它们通过cAMP脉冲相互传递信号，cAMP脉冲调节基因表达以及直接的趋化聚集。然后，它们必须识别亲属关系，只有当它们被近亲包围时，它们才会继续发育。此后，细胞分化成两种特殊的细胞类型，即前孢子细胞和前柄细胞，它们继续以复杂的方式相互传递信号，形成比例良好的子实体。通过这种方式，它们可以有序地通过依赖序列的各个阶段，而不会遗漏细胞或将细胞引向错误的路径。
Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. They are also used for communication in the social amoeba Dictyostelium discoideum when the solitary cells aggregate to form multicellular structures. Many of the signals are recognized by surface receptors that are seven-transmembrane proteins coupled to trimeric G proteins, which pass the signal on to components within the cytoplasm. Dictyostelium cells have to judge when sufficient cell density has been reached to warrant transition from growth to differentiation. They have to recognize when exogenous nutrients become limiting, and then synchronously initiate development. A few hours later they signal each other with pulses of cAMP that regulate gene expression as well as direct chemotactic aggregation. They then have to recognize kinship and only continue developing when they are surrounded by close kin. Thereafter, the cells diverge into two specialized cell types, prespore and prestalk cells, that continue to signal each other in complex ways to form well proportioned fruiting bodies. In this way they can proceed through the stages of a dependent sequence in an orderly manner without cells being left out or directed down the wrong path.
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影响因子：
4.6
作者：
Anjard, Christophe;Su, Yongxuan;Loomis, William F.
通讯作者：
Loomis, William F.
影响因子：
4
作者：
Firtel, RA
通讯作者：
Firtel, RA
影响因子：
4
作者：
Bakthavatsalam D;Brock DA;Nikravan NN;Houston KD;Hatton RD;Gomer RH
通讯作者：
Gomer RH
DOI：
10.1073/pnas.0501820102
发表时间：
2005-05-24
影响因子：
11.1
作者：
Anjard, C;Loomis, WF
通讯作者：
Loomis, WF
影响因子：
3.3
作者：
BURDINE, V;CLARKE, M
通讯作者：
CLARKE, M