Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.
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DOI：
10.1615/critrevimmunol.v30.i5.30
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发表时间：
2010
影响因子：
1.3
通讯作者：
Young MR
中科院分区：
文献类型：
--
作者：
Mailloux AW;Young MR
调节性T细胞（Regulatory T cells，Tcells）由于其有效的免疫抑制和致耐受作用而成为许多免疫学研究者的优先考虑对象。虽然Treg活性是正常免疫稳态所需的，但其数量的失调可诱导自身免疫或有助于疾病的发病机制。因此，已经做出了很大的努力来了解TdR在身体不同区域积累的机制。与其他淋巴细胞一样，TcB对涉及趋化因子、趋化因子受体、整联蛋白及其相应配体的趋化性刺激网络作出反应而迁移。然而，许多这些刺激是专有的Tibet，诱导他们的迁移，而留下传统的人口不受影响。正是这些选择性刺激导致常规效应物群体中TdR的比率增加，从而导致免疫抑制和体内平衡的变化。这篇综述探讨了在胸腺Treg发育过程中的选择性Treg运输，在稳态条件下迁移到次级淋巴组织和迁移到外周，炎症和肿瘤微环境，重点放在选择性招募Tlymphocyte到靶位置的刺激上。
Regulatory T cells (Tregs) have become a priority for many investigators in immunology due to their potent immunosuppressive and tolerogenic effects. While Treg activity is required for normal immune homeostasis, dysregulation of their numbers can induce autoimmunity or aid in the pathogenesis of disease. Therefore, great effort has been made to understand the mechanisms by which Tregs accumulate in different areas of the body. Like other lymphocytes, Tregs migrate in response to a network of chemotactic stimuli involving chemokines, chemokine receptors, integrins, and their corresponding ligands. However, many of these stimuli are exclusive to Tregs, inducing their migration while leaving conventional populations unaffected. It is these selective stimuli that result in increased ratios of Tregs among conventional effector populations, leading to changes in immune suppression and homeostasis. This review explores selective Treg trafficking during thymic Treg development, migration to secondary lymphoid tissues and emigration into the periphery during homeostatic conditions, inflammation, and the tumor microenvironment, placing emphasis on stimuli that selectively recruits Tregs to target locations.
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影响因子：
4.4
作者：
Eksteen, Bertus;Miles, Alice;Adams, David H.
通讯作者：
Adams, David H.
影响因子：
6
作者：
Baumforth, Karl R. N.;Birgersdotter, Anna;Murray, Paul G.
通讯作者：
Murray, Paul G.
影响因子：
5.4
作者：
Banz, A;Peixoto, A;Papiernik, M
通讯作者：
Papiernik, M
影响因子：
64.8
作者：
Belkaid, Y;Piccirillo, CA;Sacks, DL
通讯作者：
Sacks, DL
DOI：
10.1084/jem.20020110
发表时间：
2002-08-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Liotta F;Lazzeri E;Manetti R;Vanini V;Romagnani P;Maggi E;Romagnani S
通讯作者：
Romagnani S