In vivo measurement of intradiscal pressure changes related to thrust and non-thrust spinal manipulation in an animal model: a pilot study.
In vivo measurement of intradiscal pressure changes related to thrust and non-thrust spinal manipulation in an animal model: a pilot study.
复制标题
DOI：
10.1186/s12998-022-00445-1
复制
发表时间：
2022-09-06
影响因子：
1.9
通讯作者：
中科院分区：
文献类型：
--
作者：
椎间盘是已知的背痛产生源，并且经常是脊柱手法治疗评估和治疗的焦点。我们目前关于与脊柱手法治疗相关的椎间盘内压力（IDP）变化的大部分知识涉及尸体研究，其固有的局限性。需要更多的体内动物模型来研究与脊柱操纵和脊柱松动治疗腰背部疾病相关的椎间盘生理和分子机制。将微型压力导管 (Millar SPR-1000) 插入 3 只深度麻醉的成年猫的 L4-L5 或 L5-L6 椎间盘中（2012 年 10 月至 2013 年 5 月）。在进行器械辅助脊柱操作（Activator V® 和 Pulstar®）以及有/无手动棘突接触的机动脊柱屈曲期间记录 IDP 的变化。无棘突接触的 30° 机动屈曲使 L4-L5 椎间盘的 IDP 降低了 ~ 2.9 kPa，而 L4 棘突的物理接触又使 IDP 降低了 ~ 1.4 kPa。单独动物中 L5 物理接触的 25° 机动屈曲使 L5-L6 椎间盘的 IDP 降低 ~ 1.0 kPa。 Pulstar® 脉冲（设置 1-3）使 L4-L5 和 L5-L6 椎间盘的 IDP 增加 ~ 2.5 至 3.0 kPa。 Activator V®（设置 1-4）脉冲使 L4-L5 IDP 增加到类似程度。无论设备设置如何，IDP 振幅的净变化在两种设备上的设置中保持相当一致，这表明体内脊柱组织的粘弹性特性在到达深层背部结构（例如椎间盘）之前极大地抑制了表面施加的操纵力。这项研究标志着首次使用临床可用的仪器辅助脊柱操纵装置和/或脊柱活动程序报告猫科动物体内 IDP 的变化。这项初步研究的结果表明，猫科动物模型可用于研究与脊柱手法治疗机制相关的 IDP 变化，以及由于周围脊柱组织的粘弹性特性而导致的这些脊柱操纵力的减小。需要在此和/或其他体内动物模型中进一步研究 IDP 变化，以便更好地了解椎间盘水平脊柱手法治疗的生理效应和机制。
The intervertebral disc is a known back pain generator and is frequently the focus of spinal manipulative therapy evaluation and treatment. The majority of our current knowledge regarding intradiscal pressure (IDP) changes related to spinal manual therapy involves cadaveric studies with their inherent limitations. Additional in vivo animal models are needed to investigate intervertebral disc physiological and molecular mechanisms related to spinal manipulation and spinal mobilization treatment for low back disorders. Miniature pressure catheters (Millar SPR-1000) were inserted into either the L4-L5 or L5-L6 intervertebral disc of 3 deeply anesthetized adult cats (Oct 2012-May 2013). Changes in IDP were recorded during delivery of instrument-assisted spinal manipulation (Activator V® and Pulstar®) and motorized spinal flexion with/without manual spinous process contact. Motorized flexion of 30° without spinous contact decreased IDP of the L4-L5 disc by ~ 2.9 kPa, while physical contact of the L4 spinous process decreased IDP an additional ~ 1.4 kPa. Motorized flexion of 25° with L5 physical contact in a separate animal decreased IDP of the L5-L6 disc by ~ 1.0 kPa. Pulstar® impulses (setting 1–3) increased IDP of L4-L5 and L5-L6 intervertebral discs by ~ 2.5 to 3.0 kPa. Activator V® (setting 1–4) impulses increased L4-L5 IDP to a similar degree. Net changes in IDP amplitudes remained fairly consistent across settings on both devices regardless of device setting suggesting that viscoelastic properties of in vivo spinal tissues greatly dampen superficially applied manipulative forces prior to reaching deep back structures such as the intervertebral disc. This study marks the first time that feline in vivo changes in IDP have been reported using clinically available instrument-assisted spinal manipulation devices and/or spinal mobilization procedures. The results of this pilot study indicate that a feline model can be used to investigate IDP changes related to spinal manual therapy mechanisms as well as the diminution of these spinal manipulative forces due to viscoelastic properties of the surrounding spinal tissues. Additional investigation of IDP changes is warranted in this and/or other in vivo animal models to provide better insights into the physiological effects and mechanisms of spinal manual therapy at the intervertebral disc level.
登录
查看更多内容
影响因子：
3.5
作者：
Funabashi M;Breen AC;De Carvalho D;Pagé I;Nougarou F;Descarreaux M;Kawchuk GN
通讯作者：
Kawchuk GN
影响因子：
4.5
作者：
Funabashi, Martha;Nougarou, Francois;Kawchuk, Gregory N.
通讯作者：
Kawchuk, Gregory N.
影响因子：
3.5
作者：
Hwang, David;Gabai, Adam S.;Hsieh, Adam H.
通讯作者：
Hsieh, Adam H.
DOI：
10.1016/s0161-4754(03)00106-4
发表时间：
2003-10-01
影响因子：
1.3
作者：
Leach, RA;Parker, PL;Veal, PS
通讯作者：
Veal, PS
影响因子：
2.5
作者：
Colloca, Christopher J.;Keller, Tony S.;Harrison, Deed E.
通讯作者：
Harrison, Deed E.