Functions and mechanisms of interleukin 1 in the brain.
Functions and mechanisms of interleukin 1 in the brain.
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白细胞介素1在大脑中的功能和机制。
DOI：
10.1016/0165-6147(91)90623-z
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发表时间：
1991
影响因子：
13.8
通讯作者：
N. Rothwell
中科院分区：
文献类型：
--
作者：
N. Rothwell
IFN-γ I（IL-11）是一种具有多种作用的细胞因子，被认为是炎症和损伤的免疫和抗炎反应的介质。结婚的tlze行动的IL-？，如Nancy Rothwell所述，行为、神经内分泌功能、睡眠、发热和代谢等都是由CNS介导的。IL-1可在脑内局部合成和分泌，影响神经元和神经功能，并与脑发育和脑损伤反应密切相关。IL-2在脑内的多种效应可能涉及多种受体亚型和神经递质的复杂作用。白细胞介素1（IL-1）是一种17 kDa的肽，以两种形式存在，IL-1 α和IL-1 α，它们是单独的基因产物，仅共享约26%的序列同源物r2。IL-1是主要的分泌形式，出现在血浆和组织液中，并且是脑组织中的主要分子。IL-1是现在被称为细胞因子的一组肽中最早被鉴定的成员之一，其在生物功能上表现出多样和重叠的活性，主要与免疫功能或急性期反应（由身体在感染或损伤时立即引发的局部和全身事件的级联）的方面相关。然而，在过去的几是的里，随着对神经元功能、行为、神经内分泌系统和代谢的有效作用的证明，对细胞因子生物学，特别是IL-1的兴趣已经扩大，所有这些似乎都是由对CNS的直接作用介导的。
InferleAn I (IL-IJ, o cyfokine zuitlz diverse actions, hns been proposed ns a mediator of both be~ zeficiul and defrimenhl responses to inflammntion and injury. Marry of tlze actions of IL-?, srrch as fhose on behadour, neuroendo-crine funcfion, sleep, fever and metabolism, are mediated by fhe CNS, as described here by Nancy Rothwell. IL-1 can be synthesized and ocf locally wifhitz tke brain to inflzrence neuronnl and giial funcfion, and has been strongly implicofed in rtormnf brairz developmenf and responses to bruin injury. A nzrnzber of disfizzcf sifes and mechanisms of acfion have beerz proposed to explnb these diverse effecfs of IL-2 in fhe brain, probably irzvolving mzrltiple receptor subtypes and complex infemcfions wifk neurotransmiffcrs~~ z (i rzeurodepfides. lnterleukin 1 (IL-l), a 17 kDa peptide, exists in two forms, IL-la and IL-la, which are separate gene products sharing only about 26% sequence homolog) r2. lL-I@ is the major secreted form, ap pearing in plasma and tissue fluids, and is the predominant molecule in brain tissue. IL-1 was one of the earliest identified members of a group of peptides now known as the cytokines, which exhibit diverse and overlapping activities on biological functions, largely related to immune function or aspects of the acute phase response (the cascade of local and systemic events immediately initiated by the body on infection or injury). However, within the past few yea-. interest in cytokine biology, and in IL-l particularly, has expanded with the demonstration of potent actions on neuronal function, behaviour, neuroendocrine systems and metabolism, all of which appear to be mediated by direct actions on the CNS.
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影响因子：
20.3
作者：
C. Dinarello
通讯作者：
C. Dinarello
细胞因子的神经调节作用。
DOI：
--
发表时间：
1990
期刊：
The Yale journal of biology and medicine
影响因子：
--
作者：
Blatteis,CM
通讯作者：
Blatteis,CM
影响因子：
56.9
作者：
BREDER, CD;DINARELLO, CA;SAPER, CB
通讯作者：
SAPER, CB
对 IL-1 的热原性和急性期反应的神经机制。
DOI：
10.3109/00207458809000500
发表时间：
1988
期刊：
The International journal of neuroscience
影响因子：
--
作者：
Blatteis,CM
通讯作者：
Blatteis,CM