Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.
Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.
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DOI：
10.3109/03602532.2013.835630
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发表时间：
2013-11
影响因子：
5.9
通讯作者：
Negishi M
中科院分区：
文献类型：
--
作者：
Kodama S;Negishi M
孕烷X受体(PXR)和构造性活性雄烷受体(CAR)是核受体超家族成员，是两个主要的异种敏感转录因子。它们可以被包括治疗药物在内的广泛的亲脂性外源物质激活。除了外源物质外，类固醇激素和胆汁酸等内源性化合物也可以激活PXR和/或CAR。这些核受体调节编码酶和转运体的基因，这些酶和转运体代谢和排泄外源和内生两种物质。硫转移酶(SulfoTransferase，Sults)是一组用于解毒的酶和硫酸盐的外源化合物。一般说来，硫酸盐灭活构成了维持内生菌的动态平衡的机制。因此，破译PXR和CAR调控sult基因的分子机制对于理解sults在药物治疗或环境暴露引起的生理和病理生理过程的改变中所起的作用至关重要。
Pregnane X receptor (PXR) and constitutive active/androstane receptor (CAR), members of the nuclear receptor superfamily, are two major xeno-sensing transcription factors. They can be activated by a broad range of lipophilic xenobiotics including therapeutics drugs. In addition to xenobiotics, endogenous compounds such as steroid hormones and bile acids can also activate PXR and/or CAR. These nuclear receptors regulate genes that encode enzymes and transporters that metabolize and excrete both xenobiotics and endobiotics. Sulfotransferases (SULTs) are a group of these enzymes and sulfate xenobiotics for detoxification. In general, inactivation by sulfation constitutes the mechanism to maintain homeostasis of endobiotics. Thus, deciphering the molecular mechanism by which PXR and CAR regulate SULT genes is critical for understanding the roles of SULTs in the alterations of physiological and pathophysiological processes caused by drug treatment or environmental exposures.
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影响因子：
3.9
作者：
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通讯作者：
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DOI：
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发表时间：
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作者：
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