Subcellular organelle analysis applying confocal laser scanning microscopy to the steroid‐producing epithelial ovarian tumor: A technical note

Subcellular organelle analysis applying confocal laser scanning microscopy to the steroid‐producing epithelial ovarian tumor: A technical note
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应用共聚焦激光扫描显微镜对产生类固醇的上皮性卵巢肿瘤进行亚细胞器分析:技术说明

DOI:
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发表时间:
1997
期刊:
Pathology international (Print)
影响因子:
--
通讯作者:
R. Osamura
R. Osamura
中科院分区:
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文献类型:
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作者:
Masanori Yasuda;J. Itoh;T. Muramatsu;T. Shinozuka;H. Sasano;Y. Tsutsumi;R. Osamura

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在一名70岁的绝经后女性中检查了一种产生类固醇的上皮性卵巢肿瘤。该肿瘤的间质细胞相当致密,偶尔以tuteinization或hypothecosis为特征,这与类固醇生成有关。使用共聚焦激光扫描显微镜(CLSM)的亚细胞可视化成功地在三维图像上鉴定了线粒体样小颗粒和内质网样线性轮廓中的3β-羟基类固醇脱氢酶(HSD),以及内质网样线性轮廓中的P450-芳香酶。
An epithelial ovarian tumor with steroid production was examined in a 70‐year‐old postmenopausal female. The stromal cells of this tumor were rather dense and occasionally characterized by tuteinization or hyperthecosis, which has been associated with steroidogenesis. Subcellular visualization using confocal laser scanning microscopy (CLSM) successfully led to the identification of 3β‐hydroxysteroid dehydrogenase (HSD) in both mitochondria‐like small particles and endoplasmic reticulum‐like linear profiles, and P450‐aromatase also in endoplasmic reticulum‐like linear profiles, on the three‐dimensional images.
卵巢性索间质瘤中类固醇生成酶(芳香酶、17 α-羟化酶和胆固醇侧链裂解细胞色素 P-450)的免疫组织化学研究。
DOI: 10.1016/0046-8177(89)90010-5
发表时间: 1989
期刊: Human pathology
影响因子: 3.3
作者:
Sasano,H;Okamoto,M;Mason,JI;Simpson,ER;Mendelson,CR;Sasano,N;Silverberg,SG
通讯作者: Silverberg,SG
卵巢性索间质肿瘤中 3β-羟基类固醇脱氢酶的免疫组织化学研究。
DOI: 10.1097/00004347-199010000-00007
发表时间: 1990
期刊: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
影响因子: --
作者:
Sasano,H;Mason,JI;Sasaki,E;Yajima,A;Kimura,N;Namiki,T;Sasano,N;Nagura,H
通讯作者: Nagura,H