Oxidative stress and the amyloid beta peptide in Alzheimer's disease.
Oxidative stress and the amyloid beta peptide in Alzheimer's disease.
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阿尔茨海默病中的氧化应激和淀粉样肽。
DOI：
10.1016/j.redox.2017.10.014
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发表时间：
2018-04
期刊：
影响因子：
11.4
通讯作者：
Collin F
中科院分区：
文献类型：
--
作者：
Cheignon C;Tomas M;Bonnefont-Rousselot D;Faller P;Hureau C;Collin F
已知氧化应激在许多疾病的发病机制中发挥重要作用。特别是，它与阿尔茨海默病（AD）的病因有关，AD是一种与年龄相关的神经退行性疾病，也是老年痴呆症的最常见原因。AD的组织学标志是细胞内神经元缠结和细胞外老年斑的形成，老年斑由沿着金属离子如铜、铁或锌的聚集形式的淀粉样β肽（Aβ）组成。氧化还原活性金属离子，例如铜，当与淀粉样蛋白-β（Aβ）结合时，可以催化活性氧物质（ROS）的产生。由此产生的ROS，特别是反应性最强的羟基自由基，可能导致Aβ肽本身和周围分子（蛋白质、脂质等）的氧化损伤。本文综述了氧化应激与AD之间的联系，以及Aβ肽及其周围分子在氧化损伤中的作用。此外，金属离子在AD中的含义，它们与Aβ肽的相互作用和导致ROS产生的氧化还原性质，沿着在体外和体内氧化的Aβ肽，在分子水平上进行了讨论。氧化应激在阿尔茨海默病（AD）中起作用，AD是一种导致认知功能丧失的多因素疾病。金属离子可以结合淀粉样蛋白β肽（Aβ），并参与活性氧（ROS）的产生。氧化作用靶向神经元膜生物分子并导致膜完整性的破坏。Aβ在ROS产生过程中受损，导致聚集、ROS产生和细胞毒性。
Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer’s disease (AD), an age-related neurodegenerative disease and the most common cause of dementia in the elderly. Histopathological hallmarks of AD are intracellular neurofibrillary tangles and extracellular formation of senile plaques composed of the amyloid-beta peptide (Aβ) in aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, as for example copper, can catalyze the production of Reactive Oxygen Species (ROS) when bound to the amyloid-β (Aβ). The ROS thus produced, in particular the hydroxyl radical which is the most reactive one, may contribute to oxidative damage on both the Aβ peptide itself and on surrounding molecule (proteins, lipids, …). This review highlights the existing link between oxidative stress and AD, and the consequences towards the Aβ peptide and surrounding molecules in terms of oxidative damage. In addition, the implication of metal ions in AD, their interaction with the Aβ peptide and redox properties leading to ROS production are discussed, along with both in vitro and in vivo oxidation of the Aβ peptide, at the molecular level. Oxidative stress plays a role in Alzheimer’s disease (AD), a multifactorial disease leading to loss of cognitive functions. Metal ions can bind the amyloid beta peptide (Aβ) and are involved in the production of reactive oxygen species (ROS). Oxidation targets neuronal membrane biomolecules and leads to disruption of membrane integrity. Aβ is damaged during ROS production, with consequences regarding aggregation, ROS production and cell toxicity.
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影响因子：
7.1
作者：
Al-Hilaly YK;Williams TL;Stewart-Parker M;Ford L;Skaria E;Cole M;Bucher WG;Morris KL;Sada AA;Thorpe JR;Serpell LC
通讯作者：
Serpell LC
影响因子：
8.8
作者：
Bayir, H
通讯作者：
Bayir, H
影响因子：
2.9
作者：
Atwood, CS;Perry, G;Bush, AI
通讯作者：
Bush, AI
影响因子：
4.6
作者：
Alies, Bruno;Eury, Helene;Hureau, Christelle
通讯作者：
Hureau, Christelle
影响因子：
2.9
作者：
Baruch-Suchodolsky, Rozena;Fischer, Billia
通讯作者：
Fischer, Billia