3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery.
3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery.
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DOI：
10.18063/ijb.v7i4.418
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发表时间：
2021
影响因子：
8.4
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Mei Y;He C;Gao C;Zhu P;Lu G;Li H
本研究采用三维打印技术成功制备了聚乳酸/甲氨蝶呤（PLA/MTX）多孔支架，作为可控的药物释放装置，用于抑制肿瘤生长。扫描电子显微镜和能量色散谱仪证实MTX药物成功地纳入到聚乳酸长丝。3D打印的PLA/MTX支架允许药物分子在体外持续释放超过30天，减少注射或口服给药引起的全身毒副作用。体外细胞毒性实验表明，PLA/MTX支架对肿瘤细胞MG-63、A549、MCF-7和4 T1具有较高的抑制作用，对正常MC 3 T3-E1细胞的毒性较低。此外，体内实验结果证实，PLA/MTX支架高度抑制肿瘤生长，对器官没有明显的副作用。所有这些结果表明，3D打印的PLA/MTX支架可用作肿瘤抑制的可控药物递送系统。
In this study, porous polylactic acid/methotrexate (PLA/MTX) scaffolds were successfully fabricated by three-dimensional (3D) printing technology as controllable drug delivery devices to suppress tumor growth. Scanning electron microscopy and energy-dispersive spectrometer confirmed that MTX drug was successfully incorporated into the PLA filament. 3D-printed PLA/MTX scaffolds allow sustained release of drug molecules in vitro for more than 30 days, reducing systemic toxic side effects caused by injection or oral administration. In vitro cytotoxicity assay revealed that PLA/MTX scaffolds have a relatively high inhibitory effect on the tumor cells (MG-63, A549, MCF-7, and 4T1) and relatively low toxic effect on the normal MC3T3-E1 cells. Furthermore, results of in vivo experiments confirmed that PLA/MTX scaffolds highly suppressed tumor growth and no obvious side effects on the organs. All these results suggested that 3D-printed PLA/MTX scaffolds could be used as controllable drug delivery systems for tumor suppression.
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DOI：
10.1200/jco.2014.60.0734
发表时间：
2015-07-10
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Bielack SS;Smeland S;Whelan JS;Marina N;Jovic G;Hook JM;Krailo MD;Gebhardt M;Pápai Z;Meyer J;Nadel H;Randall RL;Deffenbaugh C;Nagarajan R;Brennan B;Letson GD;Teot LA;Goorin A;Baumhoer D;Kager L;Werner M;Lau CC;Sundby Hall K;Gelderblom H;Meyers P;Gorlick R;Windhager R;Helmke K;Eriksson M;Hoogerbrugge PM;Schomberg P;Tunn PU;Kühne T;Jürgens H;van den Berg H;Böhling T;Picton S;Renard M;Reichardt P;Gerss J;Butterfass-Bahloul T;Morris C;Hogendoorn PC;Seddon B;Calaminus G;Michelagnoli M;Dhooge C;Sydes MR;Bernstein M;EURAMOS-1 investigators
通讯作者：
EURAMOS-1 investigators
影响因子：
3.4
作者：
Andrzejewski, Jacek;Marciniak-Podsadna, Lidia
通讯作者：
Marciniak-Podsadna, Lidia
影响因子：
2.3
作者：
Jimenez, Mariano;Romero, Luis;Dominguez, Manuel
通讯作者：
Dominguez, Manuel
影响因子：
28.4
作者：
Sparano, Joseph A.;Gray, Robert J.;Sledge, George W., Jr.
通讯作者：
Sledge, George W., Jr.
影响因子：
5.4
作者：
Limongi T;Susa F;Allione M;di Fabrizio E
通讯作者：
di Fabrizio E