Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds.
Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds.
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DOI：
10.3390/pharmaceutics12090851
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发表时间：
2020-09-08
期刊：
影响因子：
5.4
通讯作者：
di Fabrizio E
中科院分区：
文献类型：
--
作者：
Limongi T;Susa F;Allione M;di Fabrizio E
介孔材料是特征在于具有在2和50 nm之间的均匀多孔尺寸的有序大孔系统的结构。典型的样品是沸石、碳分子筛、多孔金属氧化物、有机和无机多孔混合和柱撑材料、二氧化硅笼形物和笼形水合物化合物。生物化学和材料科学的进步导致了不同类型的多孔材料的设计和实现，从刚性到柔性的二维（2D）和三维（3D）骨架。目前的审查重点是使用三维打印（3DP）介孔支架适用于广泛的药物输送应用，由于其固有的高表面积和高孔体积。在第一部分中，讨论了用于药物释放应用的材料的孔隙率的重要性，重点是介孔材料。最后介绍了硬模板法和软模板法制备有序2D/3D介孔材料的研究进展。在第二部分中，3DP制造技术，包括熔融沉积成型，材料喷射喷墨打印，电子束熔化，选择性激光烧结，立体光刻和数字光处理，静电纺丝，和双光子聚合进行了描述。在最后一节中，通过最近的文献研究，大量的3D打印介孔材料，用于体外和体内药物递送应用，其中大部分与骨细胞和组织有关，在一个表格中列出并总结了所有技术和文献细节。这篇评论强调，一个非常横截面的观众，如何跨学科的某些分支的知识，如材料科学和纳米微制造，代表了越来越多的宝贵的援助，在先进的论坛的科学和技术的制药和生物制药。
Mesoporous materials are structures characterized by a well-ordered large pore system with uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite, carbon molecular sieves, porous metal oxides, organic and inorganic porous hybrid and pillared materials, silica clathrate and clathrate hydrates compounds. Improvement in biochemistry and materials science led to the design and implementation of different types of porous materials ranging from rigid to soft two-dimensional (2D) and three-dimensional (3D) skeletons. The present review focuses on the use of three-dimensional printed (3DP) mesoporous scaffolds suitable for a wide range of drug delivery applications, due to their intrinsic high surface area and high pore volume. In the first part, the importance of the porosity of materials employed for drug delivery application was discussed focusing on mesoporous materials. At the end of the introduction, hard and soft templating synthesis for the realization of ordered 2D/3D mesostructured porous materials were described. In the second part, 3DP fabrication techniques, including fused deposition modelling, material jetting as inkjet printing, electron beam melting, selective laser sintering, stereolithography and digital light processing, electrospinning, and two-photon polymerization were described. In the last section, through recent bibliographic research, a wide number of 3D printed mesoporous materials, for in vitro and in vivo drug delivery applications, most of which relate to bone cells and tissues, were presented and summarized in a table in which all the technical and bibliographical details were reported. This review highlights, to a very cross-sectional audience, how the interdisciplinarity of certain branches of knowledge, as those of materials science and nano-microfabrication are, represent a growing valuable aid in the advanced forum for the science and technology of pharmaceutics and biopharmaceutics.
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影响因子：
5.7
作者：
Boccardi E;Philippart A;Juhasz-Bortuzzo JA;Beltrán AM;Novajra G;Vitale-Brovarone C;Spiecker E;Boccaccini AR
通讯作者：
Boccaccini AR
影响因子：
4.3
作者：
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通讯作者：
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影响因子：
5
作者：
Fang, Jen-Hung;Liu, Che-Hau;Hu, Shang-Hsiu
通讯作者：
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影响因子：
2.3
作者：
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通讯作者：
Khan, Mohd Sajid
影响因子：
3.9
作者：
Deckers, Jan Patrick;Shahzad, Khuram;Kruth, Jean-Pierre
通讯作者：
Kruth, Jean-Pierre