Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy.
Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy.
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DOI：
10.1097/j.pain.0000000000002102
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发表时间：
2021-04-01
期刊：
影响因子：
7.4
通讯作者：
Schmid AB
中科院分区：
文献类型：
--
作者：
Matesanz L;Hausheer AC;Baskozos G;Bennett DLH;Schmid AB
补充数字内容可在文本中获得。严重程度超过神经性疼痛的存在与神经病变的程度和情绪健康的妥协有关。目前尚不清楚为什么一些患有卡压性神经病的患者会发展为神经性疼痛（neuP），而另一些患者则有非neuP，可能具有伤害性特征。这项横断面队列研究研究了腕管综合征（CTS）患者的躯体感觉结构和功能的变化，以及neuP的存在和严重程度所特有的情绪幸福感。根据DN4问卷将108例CTS患者分为无neuP组和伴有neuP组。后一组使用疼痛视觉模拟量表进一步细分为轻度和中度/重度neuP。N = 32名参与者作为健康对照。所有参与者都进行了临床检查、定量感觉测试、电诊断测试（EDT）和皮肤活检，以确定真皮和表皮内神经纤维的结构完整性。患者还完成了评估症状严重程度和功能缺陷、疼痛分布、睡眠质量和情绪健康的问卷调查。CTS患者中neuP的总体患病率为80%，其中63%为轻度neuP。症状严重程度和功能缺陷以及躯体感觉功能障碍随着neuP的存在和严重程度的增加而更加明显。在EDT和神经纤维完整性活检的患者组之间没有发现差异。neuP的严重程度伴随着更明显的情绪健康和睡眠质量缺陷。有趣的是，症状的域外传播在中度/重度neuP患者中更为普遍，表明存在中枢机制。NeuP在CTS患者中很常见，其严重程度与躯体感觉功能障碍的程度和情绪健康的损害有关。
Supplemental Digital Content is Available in the Text. The severity more than the presence of neuropathic pain is related to the extent of neuropathy and a compromise of emotional well-being in entrapment neuropathies. It currently remains unclear why some patients with entrapment neuropathies develop neuropathic pain (neuP), whereas others have non-neuP, presumably of nociceptive character. Studying patients with carpal tunnel syndrome (CTS), this cross-sectional cohort study investigated changes in somatosensory structure and function as well as emotional well-being specific to the presence and severity of neuP. Patients with CTS (n = 108) were subgrouped by the DN4 questionnaire into those without and with neuP. The latter group was further subdivided into mild and moderate/severe neuP using a pain visual analogue scale. N = 32 participants served as healthy controls. All participants underwent a clinical examination, quantitative sensory testing, electrodiagnostic testing (EDT), and skin biopsy to determine the structural integrity of dermal and intraepidermal nerve fibres. Patients also completed questionnaires evaluating symptom severity and functional deficits, pain distribution, sleep quality, and emotional well-being. The overall prevalence of neuP in patients with CTS was 80%, of which 63% had mild neuP. Symptom severity and functional deficits as well as somatosensory dysfunction was more pronounced with the presence and increasing severity of neuP. No difference was identified among patient groups for EDT and nerve fibre integrity on biopsies. The severity of neuP was accompanied by more pronounced deficits in emotional well-being and sleep quality. Intriguingly, extraterritorial spread of symptoms was more prevalent in patients with moderate/severe neuP, indicating the presence of central mechanisms. NeuP is common in patients with CTS, and its severity is related to the extent of somatosensory dysfunction and a compromise of emotional well-being.
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DOI：
10.1016/s0266-7681(97)80012-5
发表时间：
1997-02-01
期刊：
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME
影响因子：
--
作者：
delPino, JG;DelgadoMartinez, AD;Lovic, A
通讯作者：
Lovic, A
影响因子：
2.9
作者：
Landmann, Gunther;Dumat, Wolfgang;Riederer, Franz
通讯作者：
Riederer, Franz
DOI：
10.1016/j.neucli.2012.02.133
发表时间：
2012-06-01
影响因子：
3
作者：
Green, T. P.;Tolonen, E. U.;Kallio, M. A.
通讯作者：
Kallio, M. A.
影响因子：
7.4
作者：
Attal, Nadine;Lanteri-Minet, Michel;Bouhassira, Didier
通讯作者：
Bouhassira, Didier
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.