Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma.
Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma.
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DOI：
10.3389/fnbeh.2021.787475
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发表时间：
2021
影响因子：
3
通讯作者：
VandeVord PJ
中科院分区：
文献类型：
--
作者：
Dickerson MR;Murphy SF;Urban MJ;White Z;VandeVord PJ
长期神经精神损伤已成为现役军人和退伍军人爆炸相关创伤性脑损伤（bTBI）后日益受到关注的问题。神经精神障碍，如焦虑和抑郁，是退伍军人在受伤后数月甚至数年报告的常见合并症。为了了解爆炸伤后的这些慢性行为结果，有必要研究焦虑、抑郁和神经病理学之间的联系。当研究爆炸暴露后的认知缺陷时，海马体和运动皮层（MC）一直是人们感兴趣的区域，但对心境障碍（如重度抑郁症（MDD））的临床研究表明，这两个区域也在焦虑和抑郁的表现中发挥作用。由于焦虑和抑郁是创伤性脑损伤后常见的长期结果，因此研究海马和/或MC中由于爆炸引起的慢性病理变化如何导致这些精神障碍的发展是必要的。在这项研究中，我们将雄性大鼠暴露于重复爆炸超压（~17 psi）中，并评估了对海马和MC的慢性行为和病理影响。结果表明，重复爆炸暴露导致损伤后36周出现抑郁样行为，2周和52周出现焦虑样行为。这些行为也与52周时海马和MC区域内星形胶质细胞病理（胶质纤维酸蛋白，GFAP）和树突改变（微管相关蛋白，MAP2）相关。总的来说，这些发现支持了一个前提，即大脑内的慢性神经胶质病理改变有助于爆炸暴露后的神经精神损伤。
Long-term neuropsychiatric impairments have become a growing concern following blast-related traumatic brain injury (bTBI) in active military personnel and Veterans. Neuropsychiatric impairments such as anxiety and depression are common comorbidities that Veterans report months, even years following injury. To understand these chronic behavioral outcomes following blast injury, there is a need to study the link between anxiety, depression, and neuropathology. The hippocampus and motor cortex (MC) have been regions of interest when studying cognitive deficits following blast exposure, but clinical studies of mood disorders such as major depressive disorder (MDD) report that these two regions also play a role in the manifestation of anxiety and depression. With anxiety and depression being common long-term outcomes following bTBI, it is imperative to study how chronic pathological changes within the hippocampus and/or MC due to blast contribute to the development of these psychiatric impairments. In this study, we exposed male rats to a repeated blast overpressure (~17 psi) and evaluated the chronic behavioral and pathological effects on the hippocampus and MC. Results demonstrated that the repeated blast exposure led to depression-like behaviors 36 weeks following injury, and anxiety-like behaviors 2-, and 52-weeks following injury. These behaviors were also correlated with astrocyte pathology (glial-fibrillary acid protein, GFAP) and dendritic alterations (Microtubule-Associated Proteins, MAP2) within the hippocampus and MC regions at 52 weeks. Overall, these findings support the premise that chronic glial pathological changes within the brain contribute to neuropsychiatric impairments following blast exposure.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
4.2
作者：
Baalman, Kelli L.;Cotton, R. James;Rasband, Matthew N.
通讯作者：
Rasband, Matthew N.
影响因子：
4.1
作者：
Fakhoury, Marc;Shakkour, Zaynab;Lawand, Nada
通讯作者：
Lawand, Nada
DOI：
10.1016/j.nicl.2018.01.007
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Badea A;Kamnaksh A;Anderson RJ;Calabrese E;Long JB;Agoston DV
通讯作者：
Agoston DV
影响因子：
3.3
作者：
Cho, H. J.;Sajja, V. S. S. S.;Lee, Y. W.
通讯作者：
Lee, Y. W.