Allelic interactions heritably alter the activity of a metastable maize pl allele.

Allelic interactions heritably alter the activity of a metastable maize pl allele.
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等位基因相互作用可遗传地改变亚稳态玉米 pl 等位基因的活性。

DOI:
10.1093/genetics/141.2.709
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发表时间:
1995
期刊:
影响因子:
3.3
通讯作者:
Chandler,VL
Chandler,VL
中科院分区:
生物学2区
文献类型:
--
作者:
Hollick,JB;Patterson,GI;CoeJr,EH;Cone,KC;Chandler,VL

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玉米pl基因座编码花色素苷生物合成基因的转录激活因子。Pl-Rhoades(Pl-Rh)等位基因在几种组织中赋予稳健的紫色花青素苷色素。P1-Rh的自发衍生物,称为P1 '-桃花心木(P1'-mah),产生赋予减少的色素并且是减数分裂可遗传的。这些衍生物影响其它Pl-Rh等位基因,使得仅Pl '-mah等位基因从Pl-Rh/Pl'mah杂合子传递。遗传杂交确定染色体分离畸变不能解释这种排他性传播,并表明Pl-Rh总是改变Pl '-mah时,暴露于Pl'-mah。这种行为是副突变的标志。共分离实验表明,这种副诱变活性与pl基因座遗传连锁。通过连续杂交直观地定量pI作用,我们发现表型表达与另外两个玉米基因座B和r的副突变呈负相关。以前的分析B和r paramutation揭示了广泛的差异,并导致不同的分子机制的建议。考虑到所有三个系统的共同特征,重新激发了这三个等位基因相互作用的机制过程是相似的解释。
The maize pl locus encodes a transcriptional activator of anthocyanin biosynthetic genes. The Pl-Rhoades (Pl-Rh) allele confers robust purple anthocyanin pigment in several tissues. Spontaneous derivatives of Pl-Rh, termed Pl'-mahogany (Pl'-mah), arise that confer reduced pigment and are meiotically heritable. These derivatives influence other Pl-Rh alleles such that only Pl'-mah alleles are transmitted form a Pl-Rh/Pl'mah heterozygote. Genetic crosses establish that chromosomal segregation distortion does not explain this exclusive transmission and suggest that Pl-Rh invariably changes to Pl'-mah when exposed to Pl'-mah. Such behavior is a hallmark of paramutation. Cosegregation experiments demonstrate that this paramutagenic activity is genetically linked to the pl locus. By visually quantifying pl action through successive crosses, we find that phenotypic expression is inversely related to paramutation at two other maize loci, b and r. Previous analysis of b and r paramutation revealed extensive differences and led to suggestions of distinct molecular mechanisms. Consideration of the common features of all three systems reinvigorates the interpretation that the mechanistic processes of these three allelic interactions are similar.
DOI: 10.1002/j.1460-2075.1990.tb07431.x
发表时间: 1990-08-01
期刊: EMBO JOURNAL
影响因子: 11.4
作者:
GOFF, SA;KLEIN, TM;CHANDLER, VL
通讯作者: CHANDLER, VL
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期刊: Genetics
影响因子: 3.3
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发表时间: 1956-11
期刊: Genetics
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发表时间: 1993
期刊:
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DOI: --
发表时间: 1965
期刊: Genetics
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