Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly.
Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly.
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DOI：
10.3389/fimmu.2020.583019
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发表时间：
2020
影响因子：
7.3
通讯作者：
Akbar AN
中科院分区：
文献类型：
--
作者：
Pereira B;Xu XN;Akbar AN
免疫衰老最受关注的后果之一是随着年龄的增长，对疫苗的反应受损。虽然大多数研究报告老年人抗体反应受损与疫苗功效相关，但现在人们普遍认识到，这可能无法识别免疫系统随年龄增长而发生的可能影响疫苗功效的重要变化。 免疫衰老对疫苗接种的影响超出了抗体反应的缺陷，因为 T 细胞介导的反应在衰老过程中会重塑，并且肯定会影响疫苗接种。同样，先天免疫系统中与年龄相关的变化可能对抗原呈递和适应性免疫反应的启动产生重要影响。重要的是，被称为炎症的低水平慢性炎症状态已被证明会抑制对疫苗接种的免疫反应，旨在阻止基线炎症的药理学策略可潜在地用于增强疫苗反应。然而，目前旨在提高老年人免疫原性的策略主要集中在使用佐剂来促进局部炎症。需要更多的研究来了解炎症在疫苗反应中的作用，并协调这些看似矛盾的观察结果。改善老年人疫苗反应的替代方法包括使用更高的疫苗剂量或仅显示有限益处的替代疫苗接种途径。本综述将探讨增强老年人疫苗反应的新靶点和潜在新策略，包括使用抗炎药物和免疫调节剂。
One of the most appreciated consequences of immunosenescence is an impaired response to vaccines with advanced age. While most studies report impaired antibody responses in older adults as a correlate of vaccine efficacy, it is now widely appreciated that this may fail to identify important changes occurring in the immune system with age that may affect vaccine efficacy. The impact of immunosenescence on vaccination goes beyond the defects on antibody responses as T cell-mediated responses are reshaped during aging and certainly affect vaccination. Likewise, age-related changes in the innate immune system may have important consequences on antigen presentation and priming of adaptive immune responses. Importantly, a low-level chronic inflammatory status known as inflammaging has been shown to inhibit immune responses to vaccination and pharmacological strategies aiming at blocking baseline inflammation can be potentially used to boost vaccine responses. Yet current strategies aiming at improving immunogenicity in the elderly have mainly focused on the use of adjuvants to promote local inflammation. More research is needed to understand the role of inflammation in vaccine responses and to reconcile these seemingly paradoxical observations. Alternative approaches to improve vaccine responses in the elderly include the use of higher vaccine doses or alternative routes of vaccination showing only limited benefits. This review will explore novel targets and potential new strategies for enhancing vaccine responses in older adults, including the use of anti-inflammatory drugs and immunomodulators.
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DOI：
10.1084/jem.20090896
发表时间：
2009-08-31
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Agius E;Lacy KE;Vukmanovic-Stejic M;Jagger AL;Papageorgiou AP;Hall S;Reed JR;Curnow SJ;Fuentes-Duculan J;Buckley CD;Salmon M;Taams LS;Krueger J;Greenwood J;Klein N;Rustin MH;Akbar AN
通讯作者：
Akbar AN
影响因子：
5.5
作者：
Bartholomeus, Esther;De Neuter, Nicolas;Mortier, Geert
通讯作者：
Mortier, Geert
影响因子：
7.8
作者：
Clemens EB;van de Sandt C;Wong SS;Wakim LM;Valkenburg SA
通讯作者：
Valkenburg SA
影响因子：
9.2
作者：
Coccia M;Collignon C;Hervé C;Chalon A;Welsby I;Detienne S;van Helden MJ;Dutta S;Genito CJ;Waters NC;Deun KV;Smilde AK;Berg RAVD;Franco D;Bourguignon P;Morel S;Garçon N;Lambrecht BN;Goriely S;Most RV;Didierlaurent AM
通讯作者：
Didierlaurent AM
影响因子：
2.5
作者：
Atal, Shubham;Fatima, Zeenat
通讯作者：
Fatima, Zeenat