The evolution of human genetic and phenotypic variation in Africa.

The evolution of human genetic and phenotypic variation in Africa.
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DOI:
10.1016/j.cub.2009.11.050
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发表时间:
2010-02-23
期刊:
Current biology : CB
影响因子:
--
通讯作者:
Tishkoff SA
Tishkoff SA
中科院分区:
其他
文献类型:
--
作者:
Campbell MC;Tishkoff SA

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非洲是现代人类的诞生地,也是祖先人口在地理上向世界其他地区扩张的源头。土著非洲人的特点是种群内部和种群之间具有高度的遗传多样性。这些种群的遗传变异模式是由过去20万年发生的人口统计事件塑造的。整个非洲大陆在气候、饮食和传染病暴露方面的巨大变化也导致了现存非洲人的新的遗传和表型适应。这篇综述总结了我们对影响非洲人口多样性水平和模式的人口历史和选择压力的理解方面的一些最新进展。
Africa is the birthplace of modern humans, and is the source of the geographic expansion of ancestral populations into other regions of the world. Indigenous Africans are characterized by high levels of genetic diversity within and between populations. The pattern of genetic variation in these populations has been shaped by demographic events occurring over the last 200,000 years. The dramatic variation in climate, diet, and exposure to infectious disease across the continent has also resulted in novel genetic and phenotypic adaptations in extant Africans. This review summarizes some recent advances in our understanding of the demographic history and selective pressures that have influenced levels and patterns of diversity in African populations.
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