Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors
Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors
复制标题
淋巴毒素介导 αß T 细胞祖细胞对 γδ 细胞分化的调节
作者：
B. Silva;D. Pennington;A. Hayday
胸腺产生两种 T 细胞谱系：αβ 和 γδ，这两种细胞被认为是彼此独立发育的。因此，表达 CD4 和 CD8 辅助受体的双阳性 (DP) 胸腺细胞通常被简单地视为 CD4+ 和 CD8+ αβ T 细胞的祖细胞。相反，我们报道 DP 细胞通过依赖转录因子 RORgt 和淋巴毒素 (LT) β 受体 (LTβR) 的机制调节早期胸腺祖细胞和 γδ 细胞的分化。这一发现引发了对胸腺的重新认识，其中淋巴组织诱导型过程协调两个 T 细胞谱系的发育和功能整合。
The thymus gives rise to two T cell lineages, αβ and γδ, that are thought to develop independently of one another. Hence, double positive (DP) thymocytes expressing CD4 and CD8 coreceptors are usually viewed simply as progenitors of CD4+ and CD8+ αβ T cells. Instead we report that DP cells regulate the differentiation of early thymocyte progenitors and γδ cells, by a mechanism dependent on the transcription factor RORgt, and the lymphotoxin (LT) β receptor (LTβR). This finding provokes a revised view of the thymus, in which lymphoid tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages.
影响因子：
56.9
作者：
DETOGNI, P;GOELLNER, J;CHAPLIN, DD
通讯作者：
CHAPLIN, DD