Functions of ADP-ribose transferases in the maintenance of telomere integrity.
Functions of ADP-ribose transferases in the maintenance of telomere integrity.
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DOI：
10.1007/s00018-022-04235-z
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发表时间：
2022-03-29
期刊：
影响因子：
--
通讯作者：
Fouquerel E
中科院分区：
文献类型：
--
作者：
Muoio D;Laspata N;Fouquerel E
ADP-核糖转移酶（ART）家族包括17种催化单或多ADP-核糖基化（蛋白质的翻译后修饰）的酶。ART存在于所有亚细胞区室中，涉及越来越多的生物过程，包括DNA修复、复制、转录调节、细胞内和细胞外信号传导、病毒感染和细胞死亡。该家族的五个成员PARP 1、PARP 2、PARP 3、端锚聚合酶1和端锚聚合酶2主要描述了它们在维持基因组稳定性方面的关键功能。已经确定PARP 1、2和3的最明显的功能是DNA损伤的修复，而端锚聚合酶1和2对于维持端粒的完整性至关重要。端粒是位于真核生物染色体末端的核蛋白复合物，利用其独特的结构和相关的蛋白质组来协调其自身保护和复制所需的机制。虽然端锚聚合酶1和2在端粒的功能是众所周知的，但一些研究也将PARP 1、2和3带到了端粒保护的最前沿。端粒环境的独特性质突出了蛋白质相互作用和分子途径，与整个基因组中描述的不同。本文综述了PARP 1、PARP 2、PARP 3、端锚聚合酶1和端锚聚合酶2在维持和保存端粒完整性中的作用。
The ADP-ribose transferase (ART) family comprises 17 enzymes that catalyze mono- or poly-ADP-ribosylation, a post-translational modification of proteins. Present in all subcellular compartments, ARTs are implicated in a growing number of biological processes including DNA repair, replication, transcription regulation, intra- and extra-cellular signaling, viral infection and cell death. Five members of the family, PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 are mainly described for their crucial functions in the maintenance of genome stability. It is well established that the most describedrole of PARP1, 2 and 3 is the repair of DNA lesions while tankyrases 1 and 2 are crucial for maintaining the integrity of telomeres. Telomeres, nucleoprotein complexes located at the ends of eukaryotic chromosomes, utilize their unique structure and associated set of proteins to orchestrate the mechanisms necessary for their own protection and replication. While the functions of tankyrases 1 and 2 at telomeres are well known, several studies have also brought PARP1, 2 and 3 to the forefront of telomere protection. The singular quality of the telomeric environment has highlighted protein interactions and molecular pathways distinct from those described throughout the genome. The aim of this review is to provide an overview of the current knowledge on the multiple roles of PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 in the maintenance and preservation of telomere integrity.
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影响因子：
4.5
作者：
Ballew BJ;Joseph V;De S;Sarek G;Vannier JB;Stracker T;Schrader KA;Small TN;O'Reilly R;Manschreck C;Harlan Fleischut MM;Zhang L;Sullivan J;Stratton K;Yeager M;Jacobs K;Giri N;Alter BP;Boland J;Burdett L;Offit K;Boulton SJ;Savage SA;Petrini JH
通讯作者：
Petrini JH
影响因子：
16.8
作者：
Berti, Matteo;Chaudhuri, Arnab Ray;Thangavel, Saravanabhavan;Gomathinayagam, Shivasankari;Kenig, Sasa;Vujanovic, Marko;Odreman, Federico;Glatter, Timo;Graziano, Simona;Mendoza-Maldonado, Ramiro;Marino, Francesca;Lucic, Bojana;Biasin, Valentina;Gstaiger, Matthias;Aebersold, Ruedi;Sidorova, Julia M.;Monnat, Raymond J., Jr.;Lopes, Massimo;Vindigni, Alessandro
通讯作者：
Vindigni, Alessandro
影响因子：
4
作者：
Ame, Jean-Christophe;Fouquerel, Elise;Schreiber, Valerie
通讯作者：
Schreiber, Valerie
影响因子：
30.8
作者：
Broccoli, D;Smogorzewska, A;deLange, T
通讯作者：
deLange, T
影响因子：
56.9
作者：
CHONG, L;VANSTEENSEL, B;DELANGE, T
通讯作者：
DELANGE, T