Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study.
Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study.
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青岛市先天性心脏病发病率及危险因素的前瞻性队列研究
DOI：
10.1186/s12889-021-11034-x
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发表时间：
2021-06-02
影响因子：
4.5
通讯作者：
Xing Q
中科院分区：
文献类型：
--
作者：
Jin X;Ni W;Wang G;Wu Q;Zhang J;Li G;Jiao N;Chen W;Liu Q;Gao L;Xing Q
背景许多研究对先天性心脏病（CHD）的发病率进行了评估。然而，这些研究的结果之间存在很大的不一致性与广泛的findings.MethodsA前瞻性人口普查为基础的队列研究，在青岛，中国，从2018年8月1日至2019年4月30日。对所有当地登记的孕妇进行连续调查，从妊娠15 ~ 20周到分娩，追踪胎儿和新生儿阶段的CHD病例。Logistic回归模型应用于评估CHD和可能的危险因素之间的关联。结果产前CHD筛查阳性率为14.36/1000胎儿，CHD发病率为9.38/1000活产。Logistic回归分析结果显示，居住在农村（OR：0.771，95%CI：0.628-0.946）和有生育史（OR：0.802，95%CI：0.676-0.951）与冠心病发病呈负相关。然而，双胞胎怀孕（OR：1.957，95%CI：1.245-3.076），妊娠早期疾病（OR：1.306; 95%CI：1.048-1.628），冠心病家族史（OR：7.156; 95% CI：3.293-15.552）、有出生缺陷儿（OR：2.086; 95% CI：1.167-3.731）与冠心病的发病呈正相关。本研究中发现的CHD发病率与现有研究相似。产前CHD筛查阳性率高于新生儿CHD发病率。此外，我们的研究还发现了冠心病的危险因素，我们的研究结果可能对制定冠心病干预策略具有重要意义。
BackgroundMany studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings.MethodsA prospective census-based cohort study was conducted in Qingdao, China, from August 1, 2018 to April 30, 2019. All of the local registered pregnant women were continuously investigated and followed from 15 to 20 weeks of gestation to delivery, tracking the CHD cases in both the fetal and neonatal stages. A logistic regression model was applied to assess the association between CHD and possible risk factors.ResultsThe positive rate of prenatal CHD screening was 14.36 per 1000 fetuses and the incidence of CHD was 9.38 per 1000 live births. Results from logistic regression indicated that, living in the countryside (odds ratio, (OR): 0.771; 95% confidence interval, (CI): 0.628–0.946) and having a childbearing history (OR: 0.802; 95%CI: 0.676–0.951) were negatively associated with CHD. However, twin pregnancy (OR: 1.957, 95% CI: 1.245–3.076), illness in the first trimester (OR: 1.306; 95% CI: 1.048–1.628), a family history of CHD (OR: 7.156; 95% CI: 3.293–15.552), and having a child with a birth defect (OR: 2.086; 95% CI: 1.167–3.731) were positively associated with CHD.ConclusionCHD is a serious health problem in Qingdao. The CHD incidence found in this study was similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Moreover, CHD risk factors were identified in our study, and our findings may have great implications for formation CHD intervention strategies.
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影响因子：
4.7
作者：
Hanaoka T;Tamura N;Ito K;Sasaki S;Araki A;Ikeno T;Miyashita C;Ito S;Minakami H;Cho K;Endo T;Baba T;Miyamoto T;Sengoku K;Kishi R;other members of the Hokkaido Study on Environment and Children’s Health
通讯作者：
other members of the Hokkaido Study on Environment and Children’s Health
影响因子：
2.8
作者：
Carmichael, SL;Nelson, V;Croen, LA
通讯作者：
Croen, LA
影响因子：
5.1
作者：
HIATT, PW;MAHONY, L;TEPPER, RS
通讯作者：
TEPPER, RS
影响因子：
3.5
作者：
Mangones, Tania;Manhas, Amitoz;Brumberg, Heather L.
通讯作者：
Brumberg, Heather L.
陕西省活产儿先天性心脏病患病率及危险因素的横断面调查
影响因子：
2.4
作者：
Pei L;Kang Y;Zhao Y;Yan H
通讯作者：
Yan H