NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.

NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.
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DOI:
10.1016/j.micinf.2013.04.001
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发表时间:
2013-07
影响因子:
5.8
通讯作者:
Stehlik C
Stehlik C
中科院分区:
医学3区
文献类型:
--
作者:
Radian AD;de Almeida L;Dorfleutner A;Stehlik C

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宿主防御需要促炎细胞因子白细胞介素(IL)-1β和IL-18的成熟和释放以及诱导热凋亡细胞死亡,这取决于先天免疫细胞对炎性体内炎性半胱天冬酶的激活。几种胞质模式识别受体(PRR)已经参与了这一过程,对感染性和无菌激动剂的反应。在这里,我们总结了目前的知识炎性小体组织PRRs,强调最近描述的NLRP 7,以及它们在人类疾病的影响。
Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic Pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.
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