NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.
NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.
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DOI:
10.1016/j.micinf.2013.04.001
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发表时间:
2013-07
影响因子:
5.8
通讯作者:
Stehlik C
中科院分区:
文献类型:
--
作者:
Radian AD;de Almeida L;Dorfleutner A;Stehlik C
Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic Pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.
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DOI:
10.4049/jimmunol.0802367
发表时间:
2009-03-01
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Bryan NB;Dorfleutner A;Rojanasakul Y;Stehlik C
通讯作者:
Stehlik C
DOI:
10.4049/jimmunol.1003111
发表时间:
2011-02-01
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
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作者:
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通讯作者:
Ting JP
影响因子:
82.9
作者:
通讯作者:
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影响因子:
30.5
作者:
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通讯作者:
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作者:
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通讯作者:
Nunez, Gabriel