Chemistry, ultrastructure and porosity of monophasic and biphasic bone forming materials derived from marine algae
Chemistry, ultrastructure and porosity of monophasic and biphasic bone forming materials derived from marine algae
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海藻衍生的单相和双相成骨材料的化学、超微结构和孔隙率
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
R. Ewers
中科院分区：
文献类型：
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作者：
E. Spassova;S. Gintenreiter;E. Halwax;D. Moser;C. Schopper;R. Ewers
近几十年来对生物陶瓷的研究已经证明，无机骨的生物活性从根本上取决于化学成分和结构孔隙率的最佳组合。本研究比较了可吸收单相羟基磷灰石(HA)和几种新开发的可吸收双相羟基磷灰石/磷酸三钙(HA/TCP)复合材料的物相组成、微观结构和孔隙率。所有研究材料的最终产品中都保留了原生藻类的高度多孔的三维矿物支架，并具有明显的相互连接的微孔结构。所有测试材料的比孔隙率通常都很高：纯植生HA在1.07 cm3/g之间，不同HA/TCP比例的植生两相HA/TCP复合材料在0.65 cm3/g到1.04 cm3/g之间。与细小的多晶HA相比，生物质HA/TCP复合材料的超微结构发生了显著的变化，并且由于较大的多晶相和更细小的多晶相，其相含量也随之增加。尽管发生了这些结构变化，但在整个生产过程中，相互连接的多孔支架一直保持不变。在所研究的所有材料中，孔隙率主要基于孔径在1~10μm之间的孔隙，这是由天然藻类的结构决定的。所研究的材料具有较高的体内生物活性，其特定的化学组成和结构孔隙率是决定性的。
The research on bioceramics during the last decades has proved that the bioactivity of inorganic bone grafts depends fundamentally on an optimal combination of chemistry and structural porosity. This study presents a comparison of a resorbable monophasic hydroxyapatite (HA) and several newly developed resorbable biphasic hydroxyapatite – ß‐tricalcium phosphate (HA/TCP) composites both derived from naturally grown red marine algae with respect to the phase composition, microstructure and porosity. The highly porous three dimensional mineral scaffold of the native alga is maintained in the final products all investigated materials and possesses a pronounced interconnecting microporous structure. There are generally high values of specific porosity calculated for all tested materials: 1.07 cm3/g for pure phycogenic HA and between 0.65 cm3/g and 1.04 cm3/g for phycogenic biphasic HA/TCP composites with various HA/TCP ratios. The ultrastructure of the phycogenic HA/TCP composites changes significantly with the building and the increase of the ß‐TCP phase due to the bigger polyedric ß‐TCP crystals compared to the finer polycrystalline HA. Despite these structural changes the interconnected porous scaffold is kept throughout the production process. In all investigated materials the porosity is mainly based on pores with pore sizes between 1 and 10 μm in diameter, which is given by the structure of the natural alga. The specific chemistry combined with the structural porosity is decisive for the high in‐vivo bioactivity of the studied materials.
影响因子：
4.3
作者：
NERY, EB;LEGEROS, RZ;LEE, K
通讯作者：
LEE, K