Insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-1, growth hormone, and feeding in the newborn.
Insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-1, growth hormone, and feeding in the newborn.
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胰岛素、胰岛素样生长因子 I (IGF-I)、IGF 结合蛋白-1、生长激素和新生儿喂养。
DOI：
10.1210/jcem.83.10.5162
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
D. B. Dunger
中科院分区：
文献类型：
--
作者：
A. Ogilvy;S. Hands;C. Adcock;J. Holly;D. Matthews;V. Mohamed;J. Yudkin;A. Wilkinson;D. B. Dunger
GH、胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子结合蛋白-1(IGFBP-1)与胰岛素之间的关系对于了解早期生长发育的变化，特别是小于胎龄儿(SGA)的变化可能是至关重要的。为了研究这些关系，我们对26个婴儿(13个SGA)进行了12小时的激素谱分析，这些婴儿的平均年龄为4.5天。每10分钟测定一次GH水平，每20分钟测定一次胰岛素和胰岛素样生长因子结合蛋白1。这些激素的平均水平和IGF-I水平(来自单个样本)与出生时的大小有关。生长激素数据通过脉冲星和时间序列分析来表征激素的脉动性及其与饲料的关系。胰岛素样生长因子-I水平与出生体重和身长呈正相关(r2=0.47P=0.004和r2=0.0005)，而生长激素水平与出生体重和身长呈负相关(r2=-0.18P=0.04和r2=-0.20；P=0.03)。未发现平均生长激素水平与IGF-I之间的直接关系。适宜胎龄(AGA；平均+/-SD，82+/-61 ng/mL)的IGF-I水平高于SGA(34+/-22 ng/mL；P=0.03)。小于胎龄儿的GH水平显著高于胎龄儿[分别为17.1+/-8.2(P=0.04)、22.5+/-10.4(P=0.03)和30.7+/-15.4微g/L(P=0.04)]。小于胎龄儿的IGFBP-1平均水平也高于胎龄儿(157.4±90.7vs.62.7±43.8 ng/mLvs.62.7±43.8 ng/mLvs.62.7±43.8 ng/mL，P=0.01)。胰岛素变化与GH脉搏一致呈正相关(r=0.147；P<；0.01)，与胰岛素样生长因子结合蛋白-1呈负相关，滞后120min(r=-0.33；P<；0.0001)。综上所述，这些研究表明GH-IGF-I轴与新生儿喂养密切相关。在SGA婴儿中，IGF-I降低和IGFBP-1升高反映了生长缓慢，但GH升高和GH快速搏动可能是脂肪分解的信号。
The relationship between GH, insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and insulin may be critical to the understanding of variation in early growth, especially in the small for gestational age (SGA) baby. To investigate these relationships, we have undertaken 12-h hormone profiles in 26 babies (13 SGA) at a median of 4.5 days of age. GH levels were measured every 10 min; insulin and IGFBP-1 were measured every 20 min. Mean levels of these hormones and IGF-I levels (from a single sample) were related to size at birth. The GH data were analyzed by Pulsar and time series analysis to characterize hormone pulsatility and relationship with feeds. IGF-I levels correlated with birth weight and length (r2 = 0.47; P = 0.004, and r2 = 0.5; P = 0.0005, respectively, after allowing for gestation), whereas mean GH levels were negatively related to birth size (r2 = -0.18; P = 0.04 and r2 = -0.2; P = 0.03 for weight and length, respectively). No direct relationship between mean GH levels and IGF-I was identified. IGF-I levels were higher in appropriate for gestational age (AGA; mean +/- SD, 82+/-61 ng/mL) than in SGA (34+/-22 ng/mL; P = 0.03) babies. Baseline (mean +/- SD, 25.9+/-11.9), mean (33.9+/-14.0), and peak (45.0+/-18.1 microg/L) GH levels were higher in SGA than in AGA babies [17.1+/-8.2 (P = 0.04), 22.5+/-10.4 (P = 0.03), and 30.7+/-15.4 microg/L (P = 0.04), respectively]. Mean IGFBP-1 levels were also higher in SGA than AGA babies (157.4+/-90.7 vs. 62.7+/-43.8 ng/mL; P = 0.01). A positive correlation was identified between changes in insulin and coincident pulses of GH (r = 0.147; P < 0.01), whereas there was an inverse relationship between insulin and IGFBP-1, with a lag time 120 min (r = -0.33; P < 0.0001). In conclusion, these studies indicate that the GH-IGF-I axis is closely related to feeding in the newborn. In SGA babies, low IGF-I and elevated IGFBP-1 reflect the slow growth, but elevated GH and rapid GH pulsatility may be a signal for lipolysis.
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DOI：
10.1210/jcem.80.5.7538146
发表时间：
1995-05
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
L. Giudice;F. de Zegher;S. Gargosky;B. Dsupin;L. de las Fuentes;R. Crystal;R. Hintz;R. Rosenfeld
通讯作者：
L. Giudice;F. de Zegher;S. Gargosky;B. Dsupin;L. de las Fuentes;R. Crystal;R. Hintz;R. Rosenfeld
影响因子：
15.9
作者：
HO, KY;VELDHUIS, JD;THORNER, MO
通讯作者：
THORNER, MO
生长调节素/胰岛素样生长因子和胎儿生长。
DOI：
--
发表时间：
1987
期刊：
Journal of developmental physiology
影响因子：
--
作者：
D'Ercole,AJ
通讯作者：
D'Ercole,AJ
正常男性在两天禁食期间，生长激素 (GH) 分泌爆发频率和幅度的增加介导了 GH 分泌的增强。
DOI：
10.1210/jcem.74.4.1548337
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hartman,ML;Veldhuis,JD;Johnson,ML;Lee,MM;Alberti,KG;Samojlik,E;Thorner,MO
通讯作者：
Thorner,MO
早产儿、小婴儿、平均出生体重和大婴儿的生长激素、生长调节素 C 和不可抑制的胰岛素样活性水平比较。
影响因子：
9.8
作者：
Samaan,NA;Schultz,PN;Johnston,DA;Creasy,RW;Gonik,B
通讯作者：
Gonik,B