Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex.
Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex.
复制标题
DOI：
10.1038/s41467-018-05873-3
复制
发表时间：
2018-08-29
影响因子：
16.6
通讯作者：
Kennerley SW
中科院分区：
文献类型：
--
作者：
Cavanagh SE;Towers JP;Wallis JD;Hunt LT;Kennerley SW
竞争的帐户提出，工作记忆（WM）是由单个神经元的持续活动或动态（随时间变化）的活动在整个神经群体。在这里，我们比较了这些假设在四个区域的前额叶皮层（PFC）在一个眼动延迟反应任务，其中一个干预线索表明奖励可用于正确的眼跳。WM代表性最强的腹外侧PFC神经元具有较高的内在时间稳定性（时间常数）。在人口水平上，虽然一个稳定的记忆状态达到延迟期间，这种调整几何形状是相反的相对于线索周期的选择性，并被破坏的奖励线索。单神经元分析显示，许多神经元切换到编码奖励，而不是保持任务相关的空间选择性，直到眼跳。这些结果意味着WM是由高时间常数神经元内的动态群体水平活动实现的。而不是持久的活动，支持稳定的记忆表示，桥梁随后的显着刺激，PFC神经元可能会稳定一个动态的人口水平的过程，支持WM。工作记忆（WM）表现为单个神经元的持续活动以及动态群体代码。在这里，作者发现神经元根据当前注意力灵活地切换其编码，而那些具有稳定静息活动的神经元通过动态活动模式保持WM表征。
Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or by dynamic (time-varying) activity across a neural population. Here, we compare these hypotheses across four regions of prefrontal cortex (PFC) in an oculomotor-delayed-response task, where an intervening cue indicated the reward available for a correct saccade. WM representations were strongest in ventrolateral PFC neurons with higher intrinsic temporal stability (time-constant). At the population-level, although a stable mnemonic state was reached during the delay, this tuning geometry was reversed relative to cue-period selectivity, and was disrupted by the reward cue. Single-neuron analysis revealed many neurons switched to coding reward, rather than maintaining task-relevant spatial selectivity until saccade. These results imply WM is fulfilled by dynamic, population-level activity within high time-constant neurons. Rather than persistent activity supporting stable mnemonic representations that bridge subsequent salient stimuli, PFC neurons may stabilise a dynamic population-level process supporting WM. Working memory (WM) is represented in persistent activity of single neurons as well as a dynamic population code. Here, the authors find that neurons flexibly switch their coding according to current attention while those with stable resting activity maintain WM representations through dynamic activity patterns.
登录
查看更多内容
DOI：
10.1098/rstb.2007.2054
发表时间：
2007-09-29
影响因子：
6.3
作者：
Cisek, Paul
通讯作者：
Cisek, Paul
DOI：
10.1523/jneurosci.5353-08.2009
发表时间：
2009-03-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kennerley SW;Wallis JD
通讯作者：
Wallis JD
额叶中的神经元编码多个决策变量的值。
影响因子：
3.2
作者：
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD
通讯作者：
Wallis JD
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
影响因子：
1.2
作者：
Brunel, N;Wang, XJ
通讯作者：
Wang, XJ