Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis.
Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis.
复制标题
患有急性胰腺炎的妊娠大鼠血清甲状腺激素水平显着降低。
DOI：
10.1016/j.bbrc.2018.09.180
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Wang Wei Xing
中科院分区：
文献类型：
--
作者：
Wang Chen Yang;Zhao Liang;Hong Yu Pu;Mei Fang Chao;Zhou Yu;Shi Qiao;Guo Wen Yi;Deng Wen Hong;Chen Chen;Yu Jia;Wang Wei Xing
妊娠期急性胰腺炎（acute pancreatitis in pregnancy，APIP）是一种少见但严重的疾病，其围产儿死亡率高。本研究旨在研究和评估APIP大鼠模型的甲状腺损伤及其可能的机制。逆行注射牛磺胆酸钠建立APIP模型。假手术（SO）和APIP组在3个时间点进行。评估母体甲状腺和胰腺的组织学变化。检测孕鼠血清淀粉酶、脂肪酶活性、FT 3、FT 4、MDA、TNF-α、IL-1β水平，并检测孕鼠甲状腺组织中MIF、ICAM-1、CD 68的表达。在这项研究中，母体甲状腺损伤以及胰腺损伤发生在一个时间依赖性的方式。APIP组大鼠血清淀粉酶、脂肪酶活性及MDA、TNF-α、IL-1β水平明显升高，血清FT 3、FT 4水平明显降低，甲状腺组织MIF、ICAM-1、CD 68表达明显升高。APIP组可见甲状腺超微结构损伤。我们的研究表明，甲状腺损伤参与了大鼠实验性APIP模型。甲状腺功能紊乱程度与APIP相关，可能影响急性胰腺炎的预后。
Acute pancreatitis in pregnancy (APIP), which was thought to be a rare but severe disease, with a high perinatal mortality among maternal-fetuses. Our research aimed to study and assess thyroid injury in a rat model of APIP and its possible mechanisms. The APIP model was established by retrograde injection with sodium taurocholate. Sham-operated (SO) and APIP groups were performed at 3 time-points. Histological changes in the maternal thyroid and pancreas were assessed. The activities of serum amylase, lipase and levels of FT3, FT4, MDA, TNF-α and IL-1β were detected in maternal rats, and the expression of MIF, ICAM-1 and CD68 in the maternal thyroids were determined. In this study, maternal thyroid injury as well as pancreas injury occurred in a time-dependent manner. The activities of serum amylase, lipase and levels of MDA, TNF-α and IL-1β were markedly increased in acute pancreatitis rats, the levels of serum FT3 and FT4 were obviously decreased in APIP groups, and the expressions of MIF, ICAM-1 and CD68 were significantly increased in the thyroid of the APIP group. Ultrastructural thyroid injuries were observed in the APIP group. Our research suggests that thyroid injury is involved in the rat experimental model of APIP. The degree of thyroid dysfunction is associated with APIP, which may affect the prognosis of acute pancreatitis.
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DOI：
10.1097/01.aoa.0000414063.55545.a4
发表时间：
2012-06
期刊：
Obstetric Anesthesia Digest
影响因子：
--
作者：
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DOI：
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发表时间：
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期刊：
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