Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity.
Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity.
复制标题
DOI：
10.1177/0300060515618052
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Yang N;Zhang DL;Hao JY;Wang G
目的回顾性比较胆源性急性胰腺炎（BAP）和非胆源性急性胰腺炎（HAP）患者血清甲状腺激素（TH）和促甲状腺激素（TSH）水平，探讨其对急性胰腺炎（AP）严重程度的预测价值。将AP患者分为BAP组和HSAP组，然后进一步分为轻度AP（MAP）组和中重度AP（MSAP）组。测定血常规。测定游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和TSH水平。76例AP患者入组研究。MAP患者的FT3和TSH水平显著高于MSAP患者。与BAP组相比，HAP组的FT4和TSH水平显著降低。在MAP和MSAP患者中，HAP组的TSH水平均显著低于BAP组。促甲状腺激素与甘油三酯水平呈负相关。FT3是AP患者MSAP的危险因素，在预测AP严重程度方面也表现出中等准确性。TH和TSH随AP严重程度的增加而降低，尤以HPH患者为甚。FT3可作为早期评估AP严重程度的生物标志物。
To compare retrospectively serum levels of thyroid hormones (THs) and thyroid stimulating hormone (TSH) between patients with biliogenic acute pancreatitis (BAP) and those with hyperlipidaemic acute pancreatitis (HLAP), in order to assess their value for predicting the severity of acute pancreatitis (AP). Patients with AP were divided into BAP and HLAP groups, then further divided into either a mild AP (MAP) group or a moderately severe AP (MSAP) group. Routine blood parameters were measured. Free tri-iodothyronine (FT3), free thyroxine (FT4) and TSH levels were measured. Seventy-six patients with AP were enrolled in the study. FT3 and TSH levels were significantly higher in patients with MAP than in patients with MSAP. FT4 and TSH levels were significantly lower in the HLAP group than in the BAP group. TSH levels in both MAP and MSAP patients were significantly lower in the HLAP group than in the BAP group. TSH was inversely correlated with triglyceride levels in patients with HLAP. FT3 was a risk factor for MSAP in patients with AP and also demonstrated moderate accuracy in predicting AP severity. THs and TSH decrease with the severity of AP, especially in patients with HLAP. FT3 may be a useful biomarker for the early assessment of the severity of AP.
登录
查看更多内容
影响因子：
9
作者：
KELLER, GA;WEST, MA;SIMMONS, RL
通讯作者：
SIMMONS, RL
影响因子：
2.3
作者：
Klöppel, G
通讯作者：
Klöppel, G
影响因子：
5.4
作者：
Boelen, A;PlatvoetterSchiphorst, MC;Wiersinga, WM
通讯作者：
Wiersinga, WM
影响因子：
4.8
作者：
DUBUIS, JM;DAYER, JM;BURGER, AG
通讯作者：
BURGER, AG
DOI：
10.1053/beem.2001.0163
发表时间：
2001-12-01
影响因子：
7.4
作者：
Fliers, E;Alkemade, A;Wiersinga, WM
通讯作者：
Wiersinga, WM