Physical Function in Kidney Transplantation: Current Knowledge and Future Directions.

Physical Function in Kidney Transplantation: Current Knowledge and Future Directions.
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DOI:
10.1007/s40472-020-00271-5
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发表时间:
2020-06
影响因子:
2.1
通讯作者:
Harhay MN
Harhay MN
中科院分区:
其他
文献类型:
--
作者:
Yang D;Robinson L;Selinski C;Bajakian T;Mejia C;Harhay MN

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身体功能低下(PF)在终末期肾脏疾病患者中很常见。在这篇综述中,我们探讨了PF对肾移植(KT)和KT结果的影响的数据。我们还讨论了在kt前和kt后改善PF的最新干预措施。许多美国KT项目在评估KT候选资格时测量PF或相关结构。尽管精心挑选的低PF患者可以从生存率和生活质量方面受益于KT,但低PF降低了被列为KT的可能性,并增加了KT后不良结果的风险。最近的试验表明,锻炼是一种有希望改善KT候选人和接受者的PF的策略。PF是kt前后不良预后的潜在可改变的危险因素。需要研究确定理想的PF指标,用于KT评估和干预措施,以改善PF。
Low physical function (PF) is common among individuals with end-stage kidney disease. In this review, we explore data on the impacts of PF on access to kidney transplantation (KT) and KT outcomes. We also discuss the latest interventions to improve PF in pre- and post-KT settings. Many US KT programs measure PF or related constructs when assessing KT candidacy. Although carefully selected KT candidates with low PF can benefit from KT with respect to survival and quality of life, low PF decreases the likelihood of being listed for KT and increases the risk of adverse post-KT outcomes. Recent trials suggest that exercise is a promising strategy to improve PF among KT candidates and recipients. PF is a potentially modifiable risk factor for adverse pre- and post-KT outcomes. Research is needed to determine the ideal PF metric for use in KT evaluations and interventions to improve PF.
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发表时间: 2015-08
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