A Flexible Approach to Imaging in ABSL-3 Laboratories
A Flexible Approach to Imaging in ABSL-3 Laboratories
复制标题
ABSL-3 实验室灵活的成像方法
DOI：
10.1177/153567601502000204
复制
发表时间：
2015
影响因子：
1.5
通讯作者：
S. Sharpe
中科院分区：
文献类型：
--
作者：
M. Dennis;S. Parks;Gordon Bell;Irene Taylor;J. Lakeman;S. Sharpe
用感染性病原体进行实验挑战的动物的活体成像大大提高了从发病机制或功效研究中获得的数据的质量。这些额外的信息也提供了一个机会，通过改进研究和减少使用的动物数量来解决伦理问题。磁共振（MR）和计算机断层扫描（CT）成像模式在人类医学中被广泛用于诊断疾病和监测治疗效果。为了使基于动物的研究尽可能与临床情况相关，必须尽可能应用这些技术。对感染致病因子的动物进行成像，对于在扫描过程中确保动物健康和安全以及健康的计划提出了许多挑战。
In-life imaging of animals challenged experimentally with infectious agents greatly enhances the quality of data gained from a pathogenesis or efficacy study. This additional information also presents an opportunity to address ethical issues by refining the studies and reducing the number of animals used. Both magnetic resonance (MR) and computed tomography (CT) imaging modalities are used extensively in human medicine to diagnose disease and to monitor the efficacy of treatments. To make animal-based studies as relevant as possible to the clinical situation, such technologies must be applied wherever possible. Imaging animals infected with disease-causing agents presents a number of challenges for programs that assure health and safety as well as the well-being of the animals during the scanning process.
影响因子：
3.2
作者：
Sharpe, S. A.;Eschelbach, E.;Dennis, M. J.
通讯作者：
Dennis, M. J.